1.1.1.1 alcohol dehydrogenase hepatoma cell - 686331 1.1.1.153 sepiapterin reductase (L-erythro-7,8-dihydrobiopterin forming) hepatoma cell - 762356 1.1.1.205 IMP dehydrogenase hepatoma cell - 347916 1.1.1.211 long-chain-3-hydroxyacyl-CoA dehydrogenase hepatoma cell - 761287 1.1.1.271 GDP-L-fucose synthase hepatoma cell the enzyme is aberrantly upregulated in human hepatoma 762887 1.1.1.300 NADP-retinol dehydrogenase hepatoma cell reduced RDH11 expression level compared to hepatocytes 761488 1.1.1.40 malate dehydrogenase (oxaloacetate-decarboxylating) (NADP+) hepatoma cell - 761332 1.1.1.41 isocitrate dehydrogenase (NAD+) hepatoma cell - 712180 1.1.1.42 isocitrate dehydrogenase (NADP+) hepatoma cell - 712180 1.11.1.12 phospholipid-hydroperoxide glutathione peroxidase hepatoma cell - 725172 1.11.1.9 glutathione peroxidase hepatoma cell - 688957 1.13.11.53 acireductone dioxygenase (Ni2+-requiring) hepatoma cell - 764433 1.14.11.16 peptide-aspartate beta-dioxygenase hepatoma cell - 673915, 675183, 675861 1.14.11.16 peptide-aspartate beta-dioxygenase hepatoma cell highly expressed in 4 of 10 hepatocarcinomas, 10-fold activity increase 439254 1.14.11.66 [histone H3]-trimethyl-L-lysine9 demethylase hepatoma cell - 745949, 756531 1.14.11.69 [histone H3]-trimethyl-L-lysine36 demethylase hepatoma cell - 745949 1.14.14.18 heme oxygenase (biliverdin-producing) hepatoma cell overexpression of HO-1 -, 687147 1.14.19.1 stearoyl-CoA 9-desaturase hepatoma cell - 746433 1.14.99.38 cholesterol 25-monooxygenase hepatoma cell - 745051 1.14.99.66 [histone H3]-N6,N6-dimethyl-L-lysine4 FAD-dependent demethylase hepatoma cell - 698198 1.17.4.1 ribonucleoside-diphosphate reductase hepatoma cell - 745050 1.2.1.105 2-oxoglutarate dehydrogenase system hepatoma cell - 349006 1.2.1.12 glyceraldehyde-3-phosphate dehydrogenase (phosphorylating) hepatoma cell - -, 742477 1.2.1.36 retinal dehydrogenase hepatoma cell - 763150 1.2.4.1 pyruvate dehydrogenase (acetyl-transferring) hepatoma cell - 700236 1.3.1.21 7-dehydrocholesterol reductase hepatoma cell - 740913 1.4.1.27 glycine cleavage system hepatoma cell - 759374 1.4.3.13 protein-lysine 6-oxidase hepatoma cell - 684931 1.5.1.2 pyrroline-5-carboxylate reductase hepatoma cell - 392128 1.5.8.4 dimethylglycine dehydrogenase hepatoma cell - 743378 1.8.1.9 thioredoxin-disulfide reductase hepatoma cell - 677195 1.8.4.12 peptide-methionine (R)-S-oxide reductase hepatoma cell MsrB1 is highly expressed in HCC tissues and its expression correlates with the prognoses of patients with HCC after hepatectomy 765497 2.1.1.17 phosphatidylethanolamine N-methyltransferase hepatoma cell enzyme form PEMT2 is absent in hepatoma cells growing exponentially in vivo. Both PEMT2 and mRNA appears when cells enter the stationary phase of tumor growth 485189 2.1.1.17 phosphatidylethanolamine N-methyltransferase hepatoma cell PEMT2 protein decreases in preneoplastic nodules and virtually disappears in hepatocellular carcinoma 485195 2.1.1.5 betaine-homocysteine S-methyltransferase hepatoma cell - 673003 2.1.2.5 glutamate formimidoyltransferase hepatoma cell DU249 chicken hepatoma cells, contain p60 but no measurable formiminotransferase activity, may be due to the low expression of p60 34325 2.1.3.3 ornithine carbamoyltransferase hepatoma cell - 757879 2.3.1.26 sterol O-acyltransferase hepatoma cell - 486677, 684882 2.3.1.42 glycerone-phosphate O-acyltransferase hepatoma cell - 756338 2.3.1.48 histone acetyltransferase hepatoma cell - 756850, 757011 2.3.1.48 histone acetyltransferase hepatoma cell tissue culture cell, HTC cells 487078 2.3.1.57 diamine N-acetyltransferase hepatoma cell - 701662, 757889 2.3.1.B41 protein-long-chain fatty-acyl-lysine deacylase (NAD+) hepatoma cell - 757883 2.3.1.B41 protein-long-chain fatty-acyl-lysine deacylase (NAD+) hepatoma cell HCC cell, SIRT6 upregulation is quite prevalent in HCC tissues and closely correlated with worse overall survival, disease-relapse free survival, and HCC metastasis 757530 2.3.1.B41 protein-long-chain fatty-acyl-lysine deacylase (NAD+) hepatoma cell increased SIRT6 expression in HCC, SIRT6 expression pattern and its association with HCC metastasis, overview 757644 2.3.2.2 gamma-glutamyltransferase hepatoma cell azo dye-induced 487913 2.3.2.2 gamma-glutamyltransferase hepatoma cell primary and Yoshida ascites (AH 13) 487912 2.3.2.5 glutaminyl-peptide cyclotransferase hepatoma cell - 759074 2.4.1.101 alpha-1,3-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase hepatoma cell diethylnitrosamine- or dimethylaminoazobenzene-induced hepatoma, Morris 5123D hepatoma or AH-109A, solid or ascitic 488363 2.4.1.133 xylosylprotein 4-beta-galactosyltransferase hepatoma cell - 704930 2.4.1.144 beta-1,4-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase hepatoma cell - 488370, 637308, 638223, 638224, 638227, 736507 2.4.1.144 beta-1,4-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase hepatoma cell 7721 cells, activity during cell-cycle 638226 2.4.1.144 beta-1,4-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase hepatoma cell low activity 638223 2.4.1.144 beta-1,4-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase hepatoma cell primary, about 100fold increased activity compared to normal liver tissue 638223 2.4.1.145 alpha-1,3-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase hepatoma cell - 722374 2.4.1.155 alpha-1,6-mannosyl-glycoprotein 6-beta-N-acetylglucosaminyltransferase hepatoma cell - 675946, 759648 2.4.1.255 protein O-GlcNAc transferase hepatoma cell the level of total O-GlcNAcylation or O-GlcNAc transferase protein is increased in hepatocellular carcinoma 759542 2.4.1.38 beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase hepatoma cell - 657750, 688952 2.4.1.65 3-galactosyl-N-acetylglucosaminide 4-alpha-L-fucosyltransferase hepatoma cell - 662544 2.4.1.68 glycoprotein 6-alpha-L-fucosyltransferase hepatoma cell - 489333 2.4.1.68 glycoprotein 6-alpha-L-fucosyltransferase hepatoma cell DAB-induced hepatoma 489333 2.4.1.68 glycoprotein 6-alpha-L-fucosyltransferase hepatoma cell expression in hepatoma tissues and their surrounding tissues and in tissues with chronic disease, overview 489339 2.4.1.69 type 1 galactoside alpha-(1,2)-fucosyltransferase hepatoma cell e.g. hepatoma H35 cells, the enzyme is induced during early stages of chemical hepatocarcinogenesis in parenchymal cells of Fischer 344 rats fed a diet supplemented with 0.03% N-2-acetylaminofluorene, undetectable in normal liver tissue 489357 2.4.1.90 N-acetyllactosamine synthase hepatoma cell Hep-G2 cells 658123 2.4.2.10 orotate phosphoribosyltransferase hepatoma cell OPRT is involved in early events of invasion of hepatocellular carcinoma cells 676296 2.4.2.12 nicotinamide phosphoribosyltransferase hepatoma cell - 735872 2.4.2.30 NAD+ ADP-ribosyltransferase hepatoma cell - 736899 2.4.2.31 NAD+-protein-arginine ADP-ribosyltransferase hepatoma cell - 638116 2.4.3.1 beta-galactoside alpha-(2,6)-sialyltransferase hepatoma cell - 759660, 764855 2.5.1.18 glutathione transferase hepatoma cell - 637909, 637921 2.5.1.21 squalene synthase hepatoma cell - 658266, 738940 2.5.1.22 spermine synthase hepatoma cell - 489869 2.5.1.6 methionine adenosyltransferase hepatoma cell - 686924, 686926 2.6.1.13 ornithine aminotransferase hepatoma cell - 759413 2.6.1.44 alanine-glyoxylate transaminase hepatoma cell - 759686 2.6.1.51 serine-pyruvate transaminase hepatoma cell - 759686 2.7.1.1 hexokinase hepatoma cell - 704456 2.7.1.1 hexokinase hepatoma cell type II isozyme 662531 2.7.1.105 6-phosphofructo-2-kinase hepatoma cell - 761915 2.7.1.105 6-phosphofructo-2-kinase hepatoma cell resembles muscle enzyme 94932 2.7.1.107 diacylglycerol kinase (ATP) hepatoma cell - 761306 2.7.1.12 gluconokinase hepatoma cell - 762082 2.7.1.137 phosphatidylinositol 3-kinase hepatoma cell Fao hepatoma cells 640913 2.7.1.171 protein-fructosamine 3-kinase hepatoma cell - 760823 2.7.1.171 protein-fructosamine 3-kinase hepatoma cell overexpression 762465 2.7.1.48 uridine/cytidine kinase hepatoma cell - 761333 2.7.1.48 uridine/cytidine kinase hepatoma cell hepatoma 3924A cells, 2fold increase in activity during early log phase of prolifration 641653 2.7.1.48 uridine/cytidine kinase hepatoma cell UCK2 is significantly upregulated in hepatocellular carcinoma tissues compared to adjacent normal tissues 761333 2.7.1.48 uridine/cytidine kinase hepatoma cell UCKL1 is significantly upregulated in hepatocellular carcinoma tissues compared to adjacent normal tissues 761333 2.7.1.91 sphingosine kinase hepatoma cell - 671356, 673271 2.7.10.1 receptor protein-tyrosine kinase hepatoma cell - 490387 2.7.10.2 non-specific protein-tyrosine kinase hepatoma cell - 490349, 661445, 661461 2.7.10.2 non-specific protein-tyrosine kinase hepatoma cell HCC cell 691651 2.7.11.1 non-specific serine/threonine protein kinase hepatoma cell - 491119, 661422, 661900 2.7.11.10 IkappaB kinase hepatoma cell - 662516 2.7.11.12 cGMP-dependent protein kinase hepatoma cell - 693879 2.7.11.13 protein kinase C hepatoma cell constitutively active isozyme PKCdelta 676029 2.7.11.17 Ca2+/calmodulin-dependent protein kinase hepatoma cell - 664865 2.7.11.19 phosphorylase kinase hepatoma cell - 761283 2.7.11.2 [pyruvate dehydrogenase (acetyl-transferring)] kinase hepatoma cell - 660642, 660896, 674730, 760485 2.7.11.2 [pyruvate dehydrogenase (acetyl-transferring)] kinase hepatoma cell Fao cell line 661301 2.7.11.2 [pyruvate dehydrogenase (acetyl-transferring)] kinase hepatoma cell PDK4 660642 2.7.11.20 elongation factor 2 kinase hepatoma cell - 761286 2.7.11.24 mitogen-activated protein kinase hepatoma cell - 491741 2.7.11.27 [acetyl-CoA carboxylase] kinase hepatoma cell - 760778 2.7.11.30 receptor protein serine/threonine kinase hepatoma cell - 665532 2.7.11.31 [hydroxymethylglutaryl-CoA reductase (NADPH)] kinase hepatoma cell - 692267 2.7.4.6 nucleoside-diphosphate kinase hepatoma cell in hepatocarcinoma derived cell lines, NME4 expression is lower in cell lines with high metastatic potential 761777 2.7.4.8 guanylate kinase hepatoma cell Morris 7793 or Dunning 642686 2.7.7.19 polynucleotide adenylyltransferase hepatoma cell - 642938 2.7.7.19 polynucleotide adenylyltransferase hepatoma cell Morris hepatoma tumor cells 3924A 642946, 642951 2.7.7.19 polynucleotide adenylyltransferase hepatoma cell Morris hepatomas 3924A and 7777, relative lack of poly(A) polymerase activity is partly due to decreased level of this enzyme in the tumors, but largely due to the nonavailability of the primer-binding sites on the solubilized enzyme and to occupation of the available binding sites with an ineffective primer 642967 2.8.1.1 thiosulfate sulfurtransferase hepatoma cell only about 20% of the activity of normal liver 645502 2.8.2.1 aryl sulfotransferase hepatoma cell - 645675 2.8.2.14 bile-salt sulfotransferase hepatoma cell - 761727 2.8.2.2 alcohol sulfotransferase hepatoma cell - 761727 2.8.2.2 alcohol sulfotransferase hepatoma cell SULT2B1b mRNA levels in clinical hepatocarcinoma tumor samples are higher than in the non-tumorous tissue adjacent to the tumors -, 760454 2.8.2.4 estrone sulfotransferase hepatoma cell - 760317 3.1.2.4 3-hydroxyisobutyryl-CoA hydrolase hepatoma cell 46% reduced activity compared to healthy cells 650865 3.1.2.6 hydroxyacylglutathione hydrolase hepatoma cell Kirkman-Robbins hepatoma 37413 3.1.2.6 hydroxyacylglutathione hydrolase hepatoma cell Morris hepatoma cells 5123S 37413 3.1.3.42 [glycogen-synthase-D] phosphatase hepatoma cell - 94864 3.1.3.46 fructose-2,6-bisphosphate 2-phosphatase hepatoma cell - 94932 3.1.3.9 glucose-6-phosphatase hepatoma cell - 649729, 750010 3.1.3.9 glucose-6-phosphatase hepatoma cell hepatitis virus-induced hepatocellular carcinoma 664672 3.1.4.11 phosphoinositide phospholipase C hepatoma cell rapidly growing hepatoma 3924A 135125 3.1.4.12 sphingomyelin phosphodiesterase hepatoma cell - 678142, 678957 3.1.4.37 2',3'-cyclic-nucleotide 3'-phosphodiesterase hepatoma cell quantitative isozymes expression analysis in hepatoma cell lines 730760 3.1.4.39 alkylglycerophosphoethanolamine phosphodiesterase hepatoma cell - 696397 3.1.4.50 glycosylphosphatidylinositol phospholipase D hepatoma cell - 691854 3.1.8.1 aryldialkylphosphatase hepatoma cell - 678489 3.2.1.113 mannosyl-oligosaccharide 1,2-alpha-mannosidase hepatoma cell - 646574 3.2.1.113 mannosyl-oligosaccharide 1,2-alpha-mannosidase hepatoma cell HepG2, HepG2.2.15, AD38, and N10 752329 3.2.1.114 mannosyl-oligosaccharide 1,3-1,6-alpha-mannosidase hepatoma cell - 646574 3.2.1.130 glycoprotein endo-alpha-1,2-mannosidase hepatoma cell clone 9 -, 646732 3.2.1.45 glucosylceramidase hepatoma cell - 751699 3.2.1.51 alpha-L-fucosidase hepatoma cell not detected in adjacent tissue 667006 3.3.2.10 soluble epoxide hydrolase hepatoma cell - 707633 3.3.2.9 microsomal epoxide hydrolase hepatoma cell - 708309 3.4.13.18 cytosol nonspecific dipeptidase hepatoma cell - 679269 3.4.17.22 metallocarboxypeptidase D hepatoma cell overexpressed in hepatocellular carcinoma 731593 3.4.21.1 chymotrypsin hepatoma cell - 680927 3.4.21.73 u-Plasminogen activator hepatoma cell - 731238, 731239 3.4.21.B27 proprotein convertase 7 hepatoma cell - 731888 3.4.22.56 caspase-3 hepatoma cell - 647611, 710588, 753878 3.4.22.59 caspase-6 hepatoma cell - 697089 3.4.22.61 caspase-8 hepatoma cell - 664969, 696137, 710203 3.4.22.63 caspase-10 hepatoma cell - 710209 3.4.22.B73 SENP5 peptidase hepatoma cell - 753503 3.4.22.B75 SENP7 peptidase hepatoma cell - 752679 3.4.24.24 gelatinase A hepatoma cell - 683442 3.4.24.35 gelatinase B hepatoma cell - 701316 3.4.24.80 membrane-type matrix metalloproteinase-1 hepatoma cell - 681878 3.4.24.87 ADAMTS13 endopeptidase hepatoma cell ADAMTS13 and von Willebrand factor contents, overview 713533 3.4.99.B1 RCE1 hepatoma cell - 754247 3.5.1.6 beta-ureidopropionase hepatoma cell - 172058 3.5.2.2 dihydropyrimidinase hepatoma cell - 172058 3.5.3.1 arginase hepatoma cell - 696016 3.5.3.1 arginase hepatoma cell arginase activity in hepatoma cell is nearly 5fold and 15fold lower than in cirrhotic and normal livers, respectively. The amount of arginase I, as well as the expression of arginase I-mRNA are lower in HCC, in comparison with normal liver, and those of arginase II are significantly higher 696016 3.5.3.1 arginase hepatoma cell arginase activity in hepatoma cell is nearly 5fold and 15fold lower than in cirrhotic and normal livers, respectively. The amount of arginase I, as well as the expression of arginase I-mRNA are lower in hepatoma cell, in comparison with normal liver, and those of arginase II are significantly higher 696016 3.5.3.1 arginase hepatoma cell HCC 697070 3.5.3.15 protein-arginine deiminase hepatoma cell strong expression 666311 3.5.4.10 IMP cyclohydrolase hepatoma cell - 172163 3.5.4.6 AMP deaminase hepatoma cell - 700143 3.6.1.9 nucleotide diphosphatase hepatoma cell - 756172 3.9.1.3 phosphohistidine phosphatase hepatoma cell in patients with hepatocellular carcinoma, low expression of LHPP correlated with increased tumour severity and reduced overall survival 757801 4.1.1.17 ornithine decarboxylase hepatoma cell - 677508 4.1.1.32 phosphoenolpyruvate carboxykinase (GTP) hepatoma cell - 4365 4.1.1.32 phosphoenolpyruvate carboxykinase (GTP) hepatoma cell Reuber H365 hepatoma cells 4364 4.2.1.22 cystathionine beta-synthase hepatoma cell - 706024 4.2.1.22 cystathionine beta-synthase hepatoma cell reduced cystathionine beta-synthase 682533 4.2.1.3 aconitate hydratase hepatoma cell - 696168 4.3.1.4 formimidoyltetrahydrofolate cyclodeaminase hepatoma cell - 34325 4.3.1.4 formimidoyltetrahydrofolate cyclodeaminase hepatoma cell HepG2 cell line 34328 4.3.1.4 formimidoyltetrahydrofolate cyclodeaminase hepatoma cell isoform of the formiminotransferase cyclodeaminase enzyme complex 34325 4.3.2.1 argininosuccinate lyase hepatoma cell - 697084 5.2.1.8 peptidylprolyl isomerase hepatoma cell - 749058 6.1.1.19 arginine-tRNA ligase hepatoma cell - 672090 6.2.1.3 long-chain-fatty-acid-CoA ligase hepatoma cell - 662463, 673484, 674910 6.3.1.2 glutamine synthetase hepatoma cell - 676918 6.3.4.16 carbamoyl-phosphate synthase (ammonia) hepatoma cell - 672441, 672452, 673597 6.3.4.16 carbamoyl-phosphate synthase (ammonia) hepatoma cell hepatoid tumors of gastric and yolk sac 693935 6.3.4.3 formate-tetrahydrofolate ligase hepatoma cell - 765141 6.3.5.3 phosphoribosylformylglycinamidine synthase hepatoma cell 16, 20, 44, 7787, 7777, 3924A, 5123tc 1664 6.3.5.4 asparagine synthase (glutamine-hydrolysing) hepatoma cell - 661295, 675566 7.2.2.9 P-type Cu2+ transporter hepatoma cell Hep3B 656023 7.6.2.4 ABC-type fatty-acyl-CoA transporter hepatoma cell - 667429