1.1.1.1 alcohol dehydrogenase blood ADH3 plays an important role in systemic ethanol metabolism at higher levels of blood ethanol through activation by cytoplasmic solution hydrophobicity 667832 1.1.1.146 11beta-hydroxysteroid dehydrogenase blood samples from hepatic, renal and peripheral veins 691871 1.1.1.153 sepiapterin reductase (L-erythro-7,8-dihydrobiopterin forming) blood - -, 286013, 286014, 286024, 700603 1.1.1.153 sepiapterin reductase (L-erythro-7,8-dihydrobiopterin forming) blood mononuclear, cell culture 286016 1.1.1.196 15-hydroxyprostaglandin-D dehydrogenase (NADP+) blood platelet 347826 1.1.1.197 15-hydroxyprostaglandin dehydrogenase (NADP+) blood mesenteric vessels, arteries and veins 347828 1.1.1.205 IMP dehydrogenase blood - 685852, 690165 1.1.1.205 IMP dehydrogenase blood whole blood 686191 1.1.1.34 hydroxymethylglutaryl-CoA reductase (NADPH) blood samples of patients with cardiovascular disorders 698528 1.1.1.49 glucose-6-phosphate dehydrogenase (NADP+) blood - 655123, 656387, 699960 1.1.1.96 diiodophenylpyruvate reductase blood - 287552, 287554 1.1.3.49 (R)-mandelonitrile oxidase blood - 739691 1.1.3.8 L-gulonolactone oxidase blood - 712049 1.1.99.39 D-2-hydroxyglutarate dehydrogenase blood - 677577 1.11.1.6 catalase blood catalase activity increases with increasing blood lead level 673930 1.11.1.6 catalase blood catalase level is statistically decreased in patients with acne vulgaris compared to healthy ones 675779 1.11.1.9 glutathione peroxidase blood - 396606, 396611, 396613, 396622, 396623, 396624, 695415, 699305 1.11.1.9 glutathione peroxidase blood GPX activity was significantly higher in HIV-positive than in HIV-negative subjects. When GPX activity is compared by HIV status and ARTuse, HIV-negative subjects have the lowest median, HIV-positive subjects not taking ART have an intermediate median (11% greater than that of HIV-negative subjects), and HIV-positive subjects taking ART have the highest median (21% higher than that of the HIV-positive subjects not taking ART) 671197 1.11.2.2 myeloperoxidase blood - 764118 1.13.11.31 arachidonate 12-lipoxygenase blood - 688751 1.13.11.33 arachidonate 15-lipoxygenase blood - 688751 1.13.11.34 arachidonate 5-lipoxygenase blood - 688751, 705037, 705045, 711711, 712666, 742067, 765514 1.13.11.63 beta-carotene 15,15'-dioxygenase blood - 695441 1.14.11.1 gamma-butyrobetaine dioxygenase blood - 439290, 697453 1.14.11.29 hypoxia-inducible factor-proline dioxygenase blood - 741826, 743285 1.14.11.53 mRNA N6-methyladenine demethylase blood - 738753 1.14.11.65 [histone H3]-dimethyl-L-lysine9 demethylase blood - 754729 1.14.13.39 nitric-oxide synthase (NADPH) blood iNOS 684317 1.14.14.1 unspecific monooxygenase blood - 706089 1.14.14.55 quinine 3-monooxygenase blood - 706089 1.14.15.5 corticosterone 18-monooxygenase blood - 438758 1.14.16.4 tryptophan 5-monooxygenase blood - 684359 1.14.19.44 acyl-CoA (8-3)-desaturase blood - 734436 1.15.1.1 superoxide dismutase blood - 687311, 714572, 744746 1.16.3.1 ferroxidase blood - 437996, 438003, 438006, 438007, 438009, 438011, 438017, 438021, 438022, 438024, 438025, 438032 1.16.3.1 ferroxidase blood retroplacental blood 438008 1.16.3.1 ferroxidase blood venous blood 8 438029 1.17.3.2 xanthine oxidase blood - 686134 1.17.3.2 xanthine oxidase blood positive correlation between plasma xanthine oxidase and age of the individual 686890 1.17.4.4 vitamin-K-epoxide reductase (warfarin-sensitive) blood - 697715 1.2.1.12 glyceraldehyde-3-phosphate dehydrogenase (phosphorylating) blood - 688791 1.2.1.24 succinate-semialdehyde dehydrogenase (NAD+) blood - 710898 1.2.1.8 betaine-aldehyde dehydrogenase blood activity increases between birth and 40 days of age 390338 1.2.3.1 aldehyde oxidase blood trace amount 693075 1.2.4.4 3-methyl-2-oxobutanoate dehydrogenase (2-methylpropanoyl-transferring) blood - 686828 1.3.1.1 dihydropyrimidine dehydrogenase (NAD+) blood - 685850, 687190 1.3.1.2 dihydropyrimidine dehydrogenase (NADP+) blood - 349213, 349222, 349236, 670929, 740412 1.3.1.24 biliverdin reductase blood - 699950 1.3.1.24 biliverdin reductase blood protein detected in the infiltrating monocytes, macrophages, T cells and neutrophils as well as in circulating lymphocytes 437823 1.3.1.70 DELTA14-sterol reductase blood high expression 765069 1.3.3.3 coproporphyrinogen oxidase blood - 672827 1.3.8.4 isovaleryl-CoA dehydrogenase blood - 699381 1.3.8.4 isovaleryl-CoA dehydrogenase blood genetic mutation profile of isovaleric acidemia patients in Taiwan 676033 1.3.8.4 isovaleryl-CoA dehydrogenase blood peripheral 655248 1.3.8.6 glutaryl-CoA dehydrogenase (ETF) blood - 685869 1.3.8.7 medium-chain acyl-CoA dehydrogenase blood - 688197, 689342 1.3.8.9 very-long-chain acyl-CoA dehydrogenase blood - 689339 1.3.99.5 3-oxo-5alpha-steroid 4-dehydrogenase (acceptor) blood - 687319 1.3.99.6 3-oxo-5beta-steroid 4-dehydrogenase blood from patients late in pregnancy, before term labour, during term labour and within the first 24 h postpartum 676039 1.4.1.2 glutamate dehydrogenase blood - 695431 1.4.1.3 glutamate dehydrogenase [NAD(P)+] blood - 697371 1.4.3.2 L-amino-acid oxidase blood - 391792 1.4.3.4 monoamine oxidase blood predominantly B form 394572 1.5.1.15 methylenetetrahydrofolate dehydrogenase (NAD+) blood - 392077 1.5.1.20 methylenetetrahydrofolate reductase [NAD(P)H] blood - 684226, 684273, 684280, 684295, 684314, 684428, 684442, 684465, 684469, 684738, 684805, 685493, 685860, 685894, 685917, 685990, 686128, 686133, 686144, 686149, 686185, 686334, 686497, 686540, 686589, 686590, 686633, 686994, 687023, 687066, 687167, 687170, 687174, 687359, 687832, 687957, 688129, 688135, 688451, 688554, 688704, 688709, 688778, 689009, 689103, 689282, 689284, 689298, 689330, 689333, 689364, 689833, 689836, 690042, 690049, 690112, 690122, 690124, 690162, 690212, 705297 1.5.1.3 dihydrofolate reductase blood - 687029 1.5.1.34 6,7-dihydropteridine reductase blood - 485006, 656444 1.6.1.2 NAD(P)+ transhydrogenase (Re/Si-specific) blood - 741801 1.6.3.1 NAD(P)H oxidase (H2O2-forming) blood - 659956 1.6.3.5 renalase blood - 742961, 743215 1.6.3.5 renalase blood enzyme is secreted into the blood by the kidney 728036 1.6.5.2 NAD(P)H dehydrogenase (quinone) blood - 684474, 687895 1.8.1.7 glutathione-disulfide reductase blood glutathione reductase activity is significantly lower in leprosy as compared to the control group 688172 1.8.4.11 peptide-methionine (S)-S-oxide reductase blood - 686598 1.8.4.11 peptide-methionine (S)-S-oxide reductase blood maximal expression level of MsrA in kidney and liver, followed by heart, lung, brain, skeletal muscle, retina, testis, bone marrow, and blood 763918 2.1.1.1 nicotinamide N-methyltransferase blood - 686485, 757878 2.1.1.100 protein-S-isoprenylcysteine O-methyltransferase blood - 485032, 485034 2.1.1.13 methionine synthase blood - 703632, 705297 2.1.1.2 guanidinoacetate N-methyltransferase blood - 703632, 705297, 757529 2.1.1.20 glycine N-methyltransferase blood - 673122, 675559 2.1.1.45 thymidylate synthase blood intracellular parasites, host blood 485374 2.1.1.45 thymidylate synthase blood obtained from infected rat blood 485374 2.1.1.5 betaine-homocysteine S-methyltransferase blood - 705297 2.1.1.6 catechol O-methyltransferase blood mononuclear cell 441544 2.1.1.67 thiopurine S-methyltransferase blood - 485516, 485520, 485523, 485524, 485526, 485527, 684265, 684733, 685852, 685945, 686157, 686161, 686184, 686326, 686505, 686507, 687983, 688452, 689358, 689368, 689369, 690115, 690118, 701941, 703267, 703275, 703931, 704829, 756499, 756597 2.1.1.77 protein-L-isoaspartate(D-aspartate) O-methyltransferase blood - -, 485594, 485595, 485605, 485609, 485613, 485615, 703773 2.1.2.3 phosphoribosylaminoimidazolecarboxamide formyltransferase blood - 673127 2.1.2.5 glutamate formimidoyltransferase blood - 757669 2.1.4.1 glycine amidinotransferase blood - 485965, 703632, 705297 2.2.1.1 transketolase blood - -, 691270, 691298, 692208 2.2.1.2 transaldolase blood - 703380, 705478 2.3.1.13 glycine N-acyltransferase blood - 736179 2.3.1.23 1-acylglycerophosphocholine O-acyltransferase blood erythrocyte, probably 2 distinct enzymes 486656 2.3.1.23 1-acylglycerophosphocholine O-acyltransferase blood peripheral 659434 2.3.1.297 very-long-chain ceramide synthase blood - 758266 2.3.1.37 5-aminolevulinate synthase blood cells 486814 2.3.1.39 [acyl-carrier-protein] S-malonyltransferase blood umbilical cord vein blood 757892 2.3.1.43 phosphatidylcholine-sterol O-acyltransferase blood - 686547, 755762 2.3.1.5 arylamine N-acetyltransferase blood - 688141, 689073, 689112, 689354 2.3.1.56 aromatic-hydroxylamine O-acetyltransferase blood - 487246 2.3.1.61 dihydrolipoyllysine-residue succinyltransferase blood peripheral blood cells 487341 2.3.1.67 1-alkylglycerophosphocholine O-acetyltransferase blood - 701601, 703250 2.3.1.B43 protein-lysine desuccinylase (NAD+) blood - 755970 2.3.2.12 peptidyltransferase blood salt-washed ribosomes 487811 2.3.2.2 gamma-glutamyltransferase blood - 687030 2.3.2.2 gamma-glutamyltransferase blood 6 isoforms, serum of patients with cellular hepatic carcinoma 487956 2.3.2.2 gamma-glutamyltransferase blood dyslipidemic patients exhibiting metabolic syndrome are characterized by elevated GGT activity which is associated with perturbed metabolism of thiol compounds 684788 2.3.2.2 gamma-glutamyltransferase blood elevated GGT is significantly associated with increased cancer risk in men 685956 2.3.2.2 gamma-glutamyltransferase blood from individuals with no alcohol-related problems (NARP), individuals presenting alcohol abuse (AA) or individuals with alcohol dependence (AD). The highest gamma-glutamyltransferase values are seen in the AD group 684237 2.3.2.2 gamma-glutamyltransferase blood in a general population of children, overweight and abdominal fat distribution are associated with increased GGT. GGT activity is higher in boys than in girls as puberty starts 686309 2.3.2.2 gamma-glutamyltransferase blood leakage of enzyme by proteolysis from liver to blood serum 487909 2.3.2.2 gamma-glutamyltransferase blood serum 487906, 487909, 487932, 487933, 487934, 487949 2.3.2.2 gamma-glutamyltransferase blood the mean values of the gamma-glutamyltransferase in chronic dialysis patients and renal transplant recipients with hepatitis C virus infection are 3 or 4times above the reference limit and a greater frequency of patients evolve with values persistently elevated 690163 2.3.2.8 arginyltransferase blood - 488023 2.4.1.109 dolichyl-phosphate-mannose-protein mannosyltransferase blood - 710090 2.4.1.122 N-acetylgalactosaminide beta-1,3-galactosyltransferase blood - 693931 2.4.1.212 hyaluronan synthase blood - 672775 2.4.1.25 4-alpha-glucanotransferase blood - 489001 2.4.1.255 protein O-GlcNAc transferase blood - 708970 2.4.1.65 3-galactosyl-N-acetylglucosaminide 4-alpha-L-fucosyltransferase blood - 735422 2.4.1.66 procollagen glucosyltransferase blood distribution, not: erythrocytes 636786 2.4.1.69 type 1 galactoside alpha-(1,2)-fucosyltransferase blood - 657849 2.4.2.1 purine-nucleoside phosphorylase blood - 489705, 759799 2.4.2.1 purine-nucleoside phosphorylase blood high PNP level 759101 2.4.2.26 protein xylosyltransferase blood - 703247 2.4.2.28 S-methyl-5'-thioadenosine phosphorylase blood - 736173 2.4.2.4 thymidine phosphorylase blood - 685817 2.4.2.7 adenine phosphoribosyltransferase blood - 673115 2.4.3.1 beta-galactoside alpha-(2,6)-sialyltransferase blood - 759230 2.4.3.9 lactosylceramide alpha-2,3-sialyltransferase blood in atherosclerosis, excessive GM3 is synthesized in atherosclerotic lesions by macrophages and dendritic cells directly within the arterial walls in blood vessels additionally to the GM3 synthesis in blood plasma, the fatty acid compositions of GM3 from blood plasma low density lipoprotein and from atherosclerotic lesions differ 657703 2.5.1.18 glutathione transferase blood - 759081 2.5.1.18 glutathione transferase blood lowest expression of isoform GSTmu 759081 2.5.1.2 thiamine pyridinylase blood - 704238 2.5.1.57 N-acylneuraminate-9-phosphate synthase blood - 637814 2.5.1.6 methionine adenosyltransferase blood - 705297 2.5.1.61 hydroxymethylbilane synthase blood - 689025 2.6.1.1 aspartate transaminase blood - 674076, 677259 2.6.1.2 alanine transaminase blood - 673124, 674076, 675187, 675788, 677259 2.6.1.42 branched-chain-amino-acid transaminase blood - 640034, 640037 2.6.1.5 tyrosine transaminase blood - 675591 2.7.1.1 hexokinase blood - 640227 2.7.1.151 inositol-polyphosphate multikinase blood erythrocyte 393218 2.7.1.158 inositol-pentakisphosphate 2-kinase blood - 737644 2.7.1.30 glycerol kinase blood - 721260 2.7.1.40 pyruvate kinase blood - 673438, 673933, 677083, 709286 2.7.1.60 N-acylmannosamine kinase blood - 2269 2.7.1.74 deoxycytidine kinase blood - 672894 2.7.1.74 deoxycytidine kinase blood mononuclear cells used for experiments 671908 2.7.1.91 sphingosine kinase blood - 704989 2.7.1.91 sphingosine kinase blood higher activity of isozyme SPHK1, low activity of isozyme SPHK2 662167 2.7.1.91 sphingosine kinase blood isozymes SPHK1 and SPHK2 661860 2.7.10.1 receptor protein-tyrosine kinase blood - 673570 2.7.10.2 non-specific protein-tyrosine kinase blood - 660970, 663021, 691458, 691876 2.7.11.10 IkappaB kinase blood - 705315, 705320 2.7.11.19 phosphorylase kinase blood - 661654, 676038 2.7.11.19 phosphorylase kinase blood peripheral blood cells 690324 2.7.11.24 mitogen-activated protein kinase blood - 691280, 693552, 703573 2.7.11.24 mitogen-activated protein kinase blood whole blood assay 705046 2.7.11.30 receptor protein serine/threonine kinase blood - 761110 2.7.11.30 receptor protein serine/threonine kinase blood from patients of German origin with tentative diagnosis of hereditary hemorrhagic telangiectasia 702898 2.7.2.3 phosphoglycerate kinase blood - 642251, 642261, 642274, 642278, 678960 2.7.4.21 inositol-hexakisphosphate 5-kinase blood - 737644 2.7.4.9 dTMP kinase blood upregulation following infection with parasite Gyrodactylus salaris 692409 2.7.7.1 nicotinamide-nucleotide adenylyltransferase blood - 642786 2.8.2.18 cortisol sulfotransferase blood - 645722 2.8.2.20 protein-tyrosine sulfotransferase blood TPST-2 shows higher expression as TPST-1 705836 2.8.2.29 [heparan sulfate]-glucosamine 3-sulfotransferase 2 blood - 662996 3.1.1.1 carboxylesterase blood - 690327, 690724, 694564 3.1.1.10 tropinesterase blood - 133820 3.1.1.10 tropinesterase blood plasma 676153 3.1.1.10 tropinesterase blood serum 133814 3.1.1.2 arylesterase blood - 703470, 728957, 749840, 750340 3.1.1.2 arylesterase blood of patients with disorders of galactose metabolism. Low total antioxidant status and high galactose 1-phosphate levels may reduce activity of paraoxonase 1/arylesterase 679293 3.1.1.2 arylesterase blood PON1 activity is lower in chronic hepatitis patients compared with the control subjects 671006 3.1.1.34 lipoprotein lipase blood decreased to 78% and 73% of baseline values 2 h and 4 h after glucose administration, respectively 682283 3.1.1.34 lipoprotein lipase blood postheparin lipoprotein lipase increases by about 200% 677471 3.1.1.4 phospholipase A2 blood - 707725 3.1.1.47 1-alkyl-2-acetylglycerophosphocholine esterase blood - 652685, 670102, 670952, 690673, 691653, 691860, 693071 3.1.1.47 1-alkyl-2-acetylglycerophosphocholine esterase blood increased level in subjects with chronic cholestasis 653695 3.1.1.47 1-alkyl-2-acetylglycerophosphocholine esterase blood plasma isozyme 652009 3.1.1.47 1-alkyl-2-acetylglycerophosphocholine esterase blood red blood cells 669150 3.1.1.55 acetylsalicylate deacetylase blood - 672366, 679647 3.1.1.55 acetylsalicylate deacetylase blood cord blood and blood of adults 716004 3.1.1.55 acetylsalicylate deacetylase blood higher aspirin esterase activity contributes to the lowered response of diabetic platelets to aspirin-mediated antiplatelet therapy 672366 3.1.1.55 acetylsalicylate deacetylase blood neonatal plasma aspirin esterase activity is much lower than that in whole blood 716003 3.1.1.67 fatty-acyl-ethyl-ester synthase blood - 666181 3.1.1.7 acetylcholinesterase blood - 691870, 709675, 750919 3.1.1.79 hormone-sensitive lipase blood - 692007 3.1.1.8 cholinesterase blood - 652646, 703470 3.1.2.22 palmitoyl[protein] hydrolase blood - 650862 3.1.3.1 alkaline phosphatase blood - 681752 3.1.3.1 alkaline phosphatase blood contains liver and bone isozymes 653965 3.1.3.10 glucose-1-phosphatase blood - 134582 3.1.3.16 protein-serine/threonine phosphatase blood - 709404 3.1.3.18 phosphoglycolate phosphatase blood - 35337 3.1.3.19 glycerol-2-phosphatase blood - 694049 3.1.3.2 acid phosphatase blood - 691847 3.1.3.21 glycerol-1-phosphatase blood - 669659 3.1.3.4 phosphatidate phosphatase blood lipin-2, in circulating red blood cells, at ca. 10% of the levels observed in liver 709065 3.1.3.5 5'-nucleotidase blood - 709210 3.1.3.9 glucose-6-phosphatase blood - 134945, 715135 3.1.4.11 phosphoinositide phospholipase C blood - 692640 3.1.4.12 sphingomyelin phosphodiesterase blood - 692274, 750622 3.1.4.12 sphingomyelin phosphodiesterase blood umbilical cord blood. Zn2+-dependent sphingomyelinase acid activity is much higher than Zn2+ independent isoform activity in both fetal and mother's blood 665122 3.1.4.13 serine-ethanolaminephosphate phosphodiesterase blood trace amounts 81109 3.1.4.39 alkylglycerophosphoethanolamine phosphodiesterase blood - 714603, 715631, 715637 3.1.4.39 alkylglycerophosphoethanolamine phosphodiesterase blood present in circulating blood. ATX is responsible for bulk lysophosphatidic acid production in plasma. Stabilizes blood vessels and is required for embryonic vasculature by producing lysophosphatidic acid 680681 3.1.4.40 CMP-N-acylneuraminate phosphodiesterase blood - 135474 3.1.6.13 iduronate-2-sulfatase blood - 707032 3.1.6.13 iduronate-2-sulfatase blood patients with mucopolysaccharidosis type II 664624 3.1.6.4 N-acetylgalactosamine-6-sulfatase blood heparinized blood samples 751206 3.1.8.1 aryldialkylphosphatase blood - 691845, 749840, 750340 3.1.8.1 aryldialkylphosphatase blood of patients with disorders of galactose metabolism. Low total antioxidant status and high galactose 1-phosphate levels may reduce activity of paraoxonase 1/arylesterase 679293 3.1.8.1 aryldialkylphosphatase blood PON1 activity is lower in chronic hepatitis patients compared with the control subjects 671006 3.13.2.1 adenosylhomocysteinase blood - 703632 3.2.1.1 alpha-amylase blood - 393476 3.2.1.108 lactase blood - 701410 3.2.1.17 lysozyme blood - 729763 3.2.1.17 lysozyme blood contains exclusively g-type lysozyme 729618 3.2.1.17 lysozyme blood high expression of isoform LysC 750570 3.2.1.18 exo-alpha-sialidase blood - 697477 3.2.1.20 alpha-glucosidase blood dried blood spot specimen from patients with infantile Pompe disease 680016 3.2.1.22 alpha-galactosidase blood - 729607, 750344 3.2.1.31 beta-glucuronidase blood - 750341 3.2.1.45 glucosylceramidase blood - 714762, 751573 3.2.1.46 galactosylceramidase blood level of activity in umbilical cord blood is comparable ro that in adult blood 650731 3.2.1.50 alpha-N-acetylglucosaminidase blood - 679282 3.2.1.51 alpha-L-fucosidase blood - 749568 3.2.1.52 beta-N-acetylhexosaminidase blood elevated activity of N-acetyl-beta-hexosaminidase in subjects with asthma 680166 3.3.2.10 soluble epoxide hydrolase blood - 663254, 697032, 707303, 754798 3.3.2.6 leukotriene-A4 hydrolase blood - 696629, 696718, 698172, 707704, 709446, 731445, 752450 3.3.2.6 leukotriene-A4 hydrolase blood intraluminal thrombus 697856 3.3.2.9 microsomal epoxide hydrolase blood - 695932, 697480, 697577, 698150 3.4.11.18 methionyl aminopeptidase blood - 697409 3.4.11.7 glutamyl aminopeptidase blood - 752443 3.4.11.9 Xaa-Pro aminopeptidase blood - 699953 3.4.13.20 beta-Ala-His dipeptidase blood - 707089 3.4.13.9 Xaa-Pro dipeptidase blood - 708889, 709275 3.4.13.9 Xaa-Pro dipeptidase blood cord blood 683919 3.4.14.1 dipeptidyl-peptidase I blood - 697447 3.4.14.10 tripeptidyl-peptidase II blood - 647141 3.4.14.5 dipeptidyl-peptidase IV blood - 695876, 703263 3.4.14.5 dipeptidyl-peptidase IV blood DPP4 activity is higher in whole blood than in the blood plasma 703300 3.4.15.1 peptidyl-dipeptidase A blood - 731735 3.4.15.1 peptidyl-dipeptidase A blood no significant difference between enzyme activity in peripheral and left spermatic vein blood sample from the varicocele and control group. The somatic ACE has no causative role in pathophysiology of varicocele and varicocels related infertility 667295 3.4.15.1 peptidyl-dipeptidase A blood soluble form 755108 3.4.16.2 lysosomal Pro-Xaa carboxypeptidase blood - 36268 3.4.16.2 lysosomal Pro-Xaa carboxypeptidase blood DNA is extracted from whole blood 683041 3.4.16.5 carboxypeptidase C blood - 677595 3.4.16.5 carboxypeptidase C blood low expression level 753612 3.4.17.20 Carboxypeptidase U blood - 670054, 670058, 700206, 754518, 754521 3.4.17.20 Carboxypeptidase U blood the enzyme circulates as inactive zymogen in the blood stream becoming activated upon blood clotting 668341 3.4.17.21 Glutamate carboxypeptidase II blood - 697394 3.4.17.23 angiotensin-converting enzyme 2 blood - 732780 3.4.17.23 angiotensin-converting enzyme 2 blood coronary sinus blood, evidence against a major role for angiotensin converting enzyme-related carboxypeptidase in angiotensin peptide metabolism in the human coronary circulation 669704 3.4.17.23 angiotensin-converting enzyme 2 blood the soluble form of angiotensin-converting enzyme 2 lacks the membrane anchor and circulates in small amounts in the blood 753315 3.4.17.3 lysine carboxypeptidase blood - 668070, 670291 3.4.21.104 mannan-binding lectin-associated serine protease-2 blood - 666963, 683927 3.4.21.105 rhomboid protease blood - 708291 3.4.21.109 matriptase blood - 683489 3.4.21.20 cathepsin G blood - 691629 3.4.21.21 coagulation factor VIIa blood - 692535 3.4.21.22 coagulation factor IXa blood - 652507, 95337, 95338 3.4.21.26 prolyl oligopeptidase blood - 683926, 754864 3.4.21.26 prolyl oligopeptidase blood abnormal activity in peripheral blood 693500 3.4.21.27 coagulation factor XIa blood - 36530, 36531, 36532, 707856, 718045, 731538 3.4.21.34 plasma kallikrein blood prekallikrein expression 653115 3.4.21.35 tissue kallikrein blood - 682101, 682915 3.4.21.37 leukocyte elastase blood - 710666, 732907, 752403 3.4.21.38 coagulation factor XIIa blood - 667868, 670943, 683726, 695504, 696927, 696931, 700443, 701242, 701287, 706942, 707649, 707839, 709320, 710605, 718010, 732404 3.4.21.38 coagulation factor XIIa blood increased levels of activated coagulation factor XIIa are associated with coronary heart disease, sepsis, and diabetes 653755 3.4.21.38 coagulation factor XIIa blood venous blood samples 683828 3.4.21.39 chymase blood - 699404 3.4.21.41 complement subcomponent C1r blood highest expression 753598 3.4.21.45 complement factor I blood - 695445, 700242, 753374 3.4.21.45 complement factor I blood CFI-deficient patients have very low levels of CFI in their blood 697732 3.4.21.45 complement factor I blood the enzyme circulates in a zymogen-like state in blood 732047 3.4.21.46 complement factor D blood - 709321 3.4.21.46 complement factor D blood low expression 753616 3.4.21.46 complement factor D blood parasitized red blood cells, pRBC, infected by Plasmodium falciparum, rosetting serum dependent for the strains FCR3S1.2 and Malayan Camp 683539 3.4.21.47 alternative-complement-pathway C3/C5 convertase blood - 717421, 753082 3.4.21.5 thrombin blood - 651433, 683257, 695564 3.4.21.59 Tryptase blood - 708736, 710653 3.4.21.6 coagulation factor Xa blood - 650933, 651123, 651189, 651191, 653059, 81426 3.4.21.6 coagulation factor Xa blood factor Xa is part of the prothrombinase complex formed by factor Xa, nonenzymatic cofacor Va and Ca2+ on the phospholipid surface of platelets or endothelial cells 652731 3.4.21.68 t-Plasminogen activator blood - 683296, 732200 3.4.21.68 t-Plasminogen activator blood functions as a thrombolytic enzyme 699969 3.4.21.68 t-Plasminogen activator blood longer (more than 4 h) half-life in bloodstream circulation compared to human tPA (5-10 min) 697441 3.4.21.68 t-Plasminogen activator blood tPA has a half-life in the bloodstream in humans of 5 to 10 min. This short half-life prevents tPA from acting on subsequent and continued vessel occlusions that occur 697441 3.4.21.69 Protein C (activated) blood - 671004, 700409, 701370 3.4.21.69 Protein C (activated) blood circulation of inactive zymogen 683444 3.4.21.7 plasmin blood - 652141, 732405 3.4.21.75 Furin blood - 678910 3.4.21.76 Myeloblastin blood - 29717, 686188, 709372, 710661 3.4.21.76 Myeloblastin blood leukocyte concentrate prepared from pooled normal human blood 29721 3.4.21.77 semenogelase blood - 708774, 710659 3.4.21.77 semenogelase blood from patients with prostate diseases 708169 3.4.21.77 semenogelase blood prostate-specific antigen is absent in the blood of healthy subjects. Low frequency of positive results in patients with prostate cancer and high frequency of positive results in patients with benign prostatic hyperplasia 696921 3.4.21.78 granzyme A blood medium expression 717616 3.4.21.79 granzyme B blood - 677431, 682825 3.4.21.79 granzyme B blood basophil 679007 3.4.21.79 granzyme B blood granzyme B expression is increased in lung transplant patients 708189 3.4.21.B1 hyaluronan-binding serine protease blood circulation of HABP as a zymogen 687108 3.4.21.B2 granzyme M blood granzyme M is transiently elevated in the circulation following lipopolysaccharide administration in humans 753782 3.4.21.B59 granzyme H blood - 753108 3.4.21.B6 prostasin blood - 754338 3.4.21.B7 mannan-binding lectin-associated serine protease 1 blood - 670295 3.4.22.1 cathepsin B blood - 733892 3.4.22.15 cathepsin L blood low expression level 753596 3.4.22.26 cancer procoagulant blood - 668075 3.4.22.27 cathepsin S blood - 753606 3.4.22.27 cathepsin S blood from COPD patients 701183 3.4.22.36 caspase-1 blood - 681208 3.4.22.36 caspase-1 blood acute coronary syndromes is related to increased concentration of systemic soluble ICE. Patients with myocardial infarction demonstrate heightened systemic levels of ICE as compared to patients with stable angina and patients with unstable angina 679632 3.4.22.36 caspase-1 blood bacterial infection leads to a decrease in the mRNA levels of caspase-1 681973 3.4.22.38 cathepsin K blood - 753618 3.4.22.43 cathepsin V blood - 707906 3.4.22.54 calpain-3 blood - 649014 3.4.22.56 caspase-3 blood - 717617 3.4.22.59 caspase-6 blood after the challenges of high temperatures and Aeromonas hydrophila, the transcript expressions of Pfcasp-6 are significantly upregulated in blood and spleen 752585 3.4.22.60 caspase-7 blood and gills, second highest expression level 752586 3.4.22.62 caspase-9 blood high expression level 717527 3.4.22.63 caspase-10 blood markedly expressed in blood tissues under physiological conditions 753725 3.4.22.B72 SENP3 peptidase blood - 754964 3.4.23.34 cathepsin E blood - 30798 3.4.24.15 thimet oligopeptidase blood hypophysial portal blood 709612 3.4.24.19 procollagen C-endopeptidase blood tumor endothelial cells of malignant colorectal tissues 668838 3.4.24.21 astacin blood - 733445 3.4.24.23 matrilysin blood from umbilical cord, MMP-7 quantification, overview 708392 3.4.24.35 gelatinase B blood - 709620 3.4.24.79 pappalysin-1 blood - 683969, 697717, 697719, 699482, 699711, 700920, 701361, 733672, 735323 3.4.24.79 pappalysin-1 blood heparin administration is associated with a significant increase in PAPP-A levels, presumably because of the detachment of PAPP-A from the vessel wall 696978 3.4.24.79 pappalysin-1 blood PAPP-A is markedly elevated in the earliest hours after the onset of symptoms in patients with ST-elevated myocardial infarction treated with heparin and primary percutaneous coronary intervention 696978 3.4.24.84 Ste24 endopeptidase blood - 669751 3.4.24.86 ADAM 17 endopeptidase blood - 639000, 639005, 639011, 678668, 719050 3.4.24.86 ADAM 17 endopeptidase blood cellular suppression of TNF-alpha is measured using human whole blood (WBA) stimulated with lipopolysaccharide (LPS) 696611 3.4.24.86 ADAM 17 endopeptidase blood peripheral blood T-cells 638981 3.4.24.87 ADAMTS13 endopeptidase blood - 650725, 680056, 711576 3.4.24.87 ADAMTS13 endopeptidase blood cord blood. Neonates and children have a percentage ADANTS-13 activity similar to adults. 28/38 newborns have percentage activity within the normal range of healthy adults, 10 have significantly lower percentage activity that normalizes by day 2-3 670053 3.4.24.B10 ADAM12 endopeptidase blood of pregnant women 649557 3.4.24.B14 neprilysin-2 blood peripheral 733906 3.4.24.B15 PHEX peptidase blood - 682100 3.4.24.B4 matrix metalloproteinase-13 blood - 711825 3.4.24.B5 matrix metalloproteinase-15 blood peripheral 754240 3.4.24.B9 ADAM9 endopeptidase blood - 752452 3.5.1.114 N-acyl-aromatic-L-amino acid amidohydrolase blood lower expression level 733862 3.5.1.12 biotinidase blood - 667849, 752476 3.5.1.12 biotinidase blood serum, plasma, leukocytes 171919, 171920, 171921, 171922, 171923, 171924, 171925, 171927, 171928, 171929, 171930, 171931, 171933, 171935 3.5.1.92 pantetheine hydrolase blood - 719161 3.5.1.99 fatty acid amide hydrolase blood - 718570 3.5.2.2 dihydropyrimidinase blood - 689360 3.5.2.9 5-oxoprolinase (ATP-hydrolysing) blood peripheral mononuclear cells 209390, 209391 3.5.3.1 arginase blood - 703632 3.5.3.1 arginase blood tissues grouped based on their expression as follows, from lowest to highest: 1. intestine; 2. adipose tissue, spleen, blood, head kidney, scales and tail fin; 3. adipose fin, brain, heart, gonad, muscle and thymus; 4. skin; 5. gills and liver; 6. posterior kidney 753605 3.5.3.1 arginase blood tissues grouped based on their expression as follows, from lowest to highest: 1. liver; 2. intestine and tail fin; 3. adipose tissue, spleen, gills and scales; 4. adipose fin, skin, blood, posterior kidney, gonad, head kidney and thymus; 5. heart; 6. brain and muscle 753605 3.5.3.1 arginase blood tissues grouped based on their expression as follows, from lowest to highest: 1. liver; 2. tail fin; 3. adipose tissue, intestine, posterior kidney, head kidney, heart and skin; 4. blood, gonad, scales, gills, spleen, brain, thymus; 5. adipose fin and muscle 753605 3.5.3.1 arginase blood tissues grouped based on their expression as follows, from lowest to highest: 1. tail fin, intestine and scales; 2. adipose tissue, spleen and head kidney; 3. adipose fin and posterior kidney; 4. blood, muscle and thymus; 5. gills; 6. brain, skin, heart, gonad and liver 753605 3.5.3.15 protein-arginine deiminase blood PADI4 is significantly overexpressed in blood of rheumatoid arthritis. Genetic variation within PADI4 is not a major risk factor for rheumatoid arzhritis in Caucasians 666905 3.5.3.18 dimethylargininase blood - 667159, 669780 3.5.4.16 GTP cyclohydrolase I blood - 209540 3.5.4.37 double-stranded RNA adenine deaminase blood high expression 719533 3.5.4.4 adenosine deaminase blood LADA 667032 3.5.4.5 cytidine deaminase blood - 699156, 700510 3.5.4.6 AMP deaminase blood the study fails to confirm a survival benefit among heart failure patients carrying the AMPD1 T-allele (C34T) 669568 3.6.1.17 bis(5'-nucleosyl)-tetraphosphatase (asymmetrical) blood - 209906 3.6.1.2 trimetaphosphatase blood - 694049 3.7.1.4 phloretin hydrolase blood - 673123 3.7.1.4 phloretin hydrolase blood blood samples are used for genotyping 687838 4.1.1.17 ornithine decarboxylase blood - 703632 4.1.1.2 oxalate decarboxylase blood - 4103 4.1.1.28 aromatic-L-amino-acid decarboxylase blood from children with neuroblastoma 692661 4.1.1.28 aromatic-L-amino-acid decarboxylase blood sample source for DNA isolation from patients with AADC deficiency 692189 4.1.1.90 peptidyl-glutamate 4-carboxylase blood - 726845 4.1.2.27 sphinganine-1-phosphate aldolase blood - 748338 4.1.3.4 hydroxymethylglutaryl-CoA lyase blood - 678938 4.1.3.6 citrate (pro-3S)-lyase blood for DNA isolation 694565 4.2.1.1 carbonic anhydrase blood - 650271, 650522, 652642, 652647 4.2.1.1 carbonic anhydrase blood lysate contains carbonic anhydrase I, II and III 33541 4.2.1.11 phosphopyruvate hydratase blood - 33611 4.2.1.11 phosphopyruvate hydratase blood enolase I 33604 4.2.1.2 fumarate hydratase blood - 697077 4.2.1.22 cystathionine beta-synthase blood - 5605 4.2.1.22 cystathionine beta-synthase blood hyperhomocysteinaemia is a metabolic disorder associated with the development of premature atherosclerosis. Cystathionine beta-synthase activity is significantly decreased in mice with a plasma homocysteine value greater than 0.015 mg 679633 4.2.1.24 porphobilinogen synthase blood - 210726, 681018, 694568, 695128, 702882, 714758, 747241 4.2.1.24 porphobilinogen synthase blood delta-ALA-D activity in patients with chronic renal failure with hemodialysis treatment and in patients not undergoing hemodialysis is lower when compared to the control group. delta-ALA-D activity correlates positively with hemoglobin content 678572 4.2.1.24 porphobilinogen synthase blood delta-ALA-D activity is decreased in situations associated to hyperglycemia maintained for long periods. Hypofunction of the thyroid gland, when non-compensated, increase the activity of delta-ALA-D 679258 4.2.1.24 porphobilinogen synthase blood venous 664549 4.3.2.9 gamma-glutamylcyclotransferase blood - 687744 4.4.1.1 cystathionine gamma-lyase blood - 710055 4.4.1.20 leukotriene-C4 synthase blood - 678958, 695153 4.4.1.5 lactoylglutathione lyase blood - 709820 4.6.1.14 glycosylphosphatidylinositol diacylglycerol-lyase blood - 708444 4.6.1.19 ribonuclease T2 blood - 655245 5.1.99.4 alpha-methylacyl-CoA racemase blood - 704836 5.3.1.21 corticosteroid side-chain-isomerase blood - 2654 5.3.1.21 corticosteroid side-chain-isomerase blood erythrocytes show the highest activity, plasma low, and white blood cells low but highly variable levels of enzyme, circulating isomerase is derived in part from tissue sources and is in part an intrinsic blood enzyme 2654 5.3.1.6 ribose-5-phosphate isomerase blood one electrophorectic form 2777 5.6.1.5 proteasome ATPase blood - 670134 6.1.1.2 tryptophan-tRNA ligase blood - 650116 6.2.1.76 malonate-CoA ligase blood high expression 765555 6.3.2.3 glutathione synthase blood - 1223 6.3.4.16 carbamoyl-phosphate synthase (ammonia) blood - 675859 6.3.4.3 formate-tetrahydrofolate ligase blood - 673440 6.3.4.4 adenylosuccinate synthase blood - 690685 6.3.4.5 argininosuccinate synthase blood - 703248, 715188 6.3.5.4 asparagine synthase (glutamine-hydrolysing) blood - 661391 6.4.1.2 acetyl-CoA carboxylase blood - 662694 7.2.2.10 P-type Ca2+ transporter blood - 667623, 718751 7.6.2.4 ABC-type fatty-acyl-CoA transporter blood - 689002