2.1.1.77 protein-L-isoaspartate(D-aspartate) O-methyltransferase astrocytoma cell line treatment of astrocytoma cells (U-87) with direct pharmacological GSK-3 inhibitors stimulate PIMT expression (2fold). Results demonstrate regulation of PIMT expression by GSK-3 inhibitor lithium at both the transcriptional and the translational levels. Inhibition by siRNA of GSK-3 and beta-catenin modulates expression of the PIMT in accordance with GSK-3 pharmacological inhibition. Valproic acid up-regulates phospho-GSK-3b (Ser9), beta-catenin and PIMT levels similarly to lithium 3.1.3.11 fructose-bisphosphatase astrocytoma cell line cell line 1321N1 3.1.3.36 phosphoinositide 5-phosphatase astrocytoma cell line - 6.3.2.2 glutamate-cysteine ligase astrocytoma cell line malignant