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Literature summary extracted from

  • Eid, T.; Ghosh, A.; Wang, Y.; Beckstroem, H.; Zaveri, H.P.; Lee, T.S.; Lai, J.C.; Malthankar-Phatak, G.H.; de Lanerolle, N.C.
    Recurrent seizures and brain pathology after inhibition of glutamine synthetase in the hippocampus in rats (2008), Brain, 131, 2061-2070.
    View publication on PubMedView publication on EuropePMC

Application

EC Number Application Comment Organism
6.3.1.2 medicine restoration of glutamine synthetase may represent an approach to therapeutic intervention in mesial temporal lobe epilepsy Homo sapiens

Inhibitors

EC Number Inhibitors Comment Organism Structure
6.3.1.2 methionine sulfoximine
-
Homo sapiens
6.3.1.2 methionine sulfoximine irreversible inhibition up to 97% in vivo after longterm treatment over 3 h by Intracranial infusion Rattus norvegicus

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
6.3.1.2 ATP + L-glutamate + NH3 Homo sapiens
-
ADP + phosphate + L-glutamine
-
?
6.3.1.2 ATP + L-glutamate + NH3 Rattus norvegicus
-
ADP + phosphate + L-glutamine
-
?
6.3.1.2 additional information Rattus norvegicus deficiency in hippocampal glutamine synthetase causes recurrent seizures, even in the absence of classical mesial temporal sclerosis, overview ?
-
?
6.3.1.2 additional information Homo sapiens extracellular glutamate in the hippocampus causes recurrent seizures and is involved in medically intractable mesial temporal lobe epilepsy, MTLE, overview ?
-
?

Organism

EC Number Organism UniProt Comment Textmining
6.3.1.2 Homo sapiens
-
male Sprague Dawley rats
-
6.3.1.2 Rattus norvegicus
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
6.3.1.2 brain
-
Homo sapiens
-
6.3.1.2 brain
-
Rattus norvegicus
-
6.3.1.2 hippocampus
-
Homo sapiens
-
6.3.1.2 hippocampus
-
Rattus norvegicus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
6.3.1.2 ATP + L-glutamate + NH3
-
Homo sapiens ADP + phosphate + L-glutamine
-
?
6.3.1.2 ATP + L-glutamate + NH3
-
Rattus norvegicus ADP + phosphate + L-glutamine
-
?
6.3.1.2 additional information deficiency in hippocampal glutamine synthetase causes recurrent seizures, even in the absence of classical mesial temporal sclerosis, overview Rattus norvegicus ?
-
?
6.3.1.2 additional information extracellular glutamate in the hippocampus causes recurrent seizures and is involved in medically intractable mesial temporal lobe epilepsy, MTLE, overview Homo sapiens ?
-
?

Synonyms

EC Number Synonyms Comment Organism
6.3.1.2 Glutamine synthetase
-
Homo sapiens
6.3.1.2 Glutamine synthetase
-
Rattus norvegicus

Cofactor

EC Number Cofactor Comment Organism Structure
6.3.1.2 ATP
-
Homo sapiens
6.3.1.2 ATP
-
Rattus norvegicus