EC Number | Application | Comment | Organism |
---|---|---|---|
6.3.1.2 | medicine | restoration of glutamine synthetase may represent an approach to therapeutic intervention in mesial temporal lobe epilepsy | Homo sapiens |
EC Number | Inhibitors | Comment | Organism | Structure |
---|---|---|---|---|
6.3.1.2 | methionine sulfoximine | - |
Homo sapiens | |
6.3.1.2 | methionine sulfoximine | irreversible inhibition up to 97% in vivo after longterm treatment over 3 h by Intracranial infusion | Rattus norvegicus |
EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
6.3.1.2 | ATP + L-glutamate + NH3 | Homo sapiens | - |
ADP + phosphate + L-glutamine | - |
? | |
6.3.1.2 | ATP + L-glutamate + NH3 | Rattus norvegicus | - |
ADP + phosphate + L-glutamine | - |
? | |
6.3.1.2 | additional information | Rattus norvegicus | deficiency in hippocampal glutamine synthetase causes recurrent seizures, even in the absence of classical mesial temporal sclerosis, overview | ? | - |
? | |
6.3.1.2 | additional information | Homo sapiens | extracellular glutamate in the hippocampus causes recurrent seizures and is involved in medically intractable mesial temporal lobe epilepsy, MTLE, overview | ? | - |
? |
EC Number | Organism | UniProt | Comment | Textmining |
---|---|---|---|---|
6.3.1.2 | Homo sapiens | - |
male Sprague Dawley rats | - |
6.3.1.2 | Rattus norvegicus | - |
- |
- |
EC Number | Source Tissue | Comment | Organism | Textmining |
---|---|---|---|---|
6.3.1.2 | brain | - |
Homo sapiens | - |
6.3.1.2 | brain | - |
Rattus norvegicus | - |
6.3.1.2 | hippocampus | - |
Homo sapiens | - |
6.3.1.2 | hippocampus | - |
Rattus norvegicus | - |
EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
6.3.1.2 | ATP + L-glutamate + NH3 | - |
Homo sapiens | ADP + phosphate + L-glutamine | - |
? | |
6.3.1.2 | ATP + L-glutamate + NH3 | - |
Rattus norvegicus | ADP + phosphate + L-glutamine | - |
? | |
6.3.1.2 | additional information | deficiency in hippocampal glutamine synthetase causes recurrent seizures, even in the absence of classical mesial temporal sclerosis, overview | Rattus norvegicus | ? | - |
? | |
6.3.1.2 | additional information | extracellular glutamate in the hippocampus causes recurrent seizures and is involved in medically intractable mesial temporal lobe epilepsy, MTLE, overview | Homo sapiens | ? | - |
? |
EC Number | Synonyms | Comment | Organism |
---|---|---|---|
6.3.1.2 | Glutamine synthetase | - |
Homo sapiens |
6.3.1.2 | Glutamine synthetase | - |
Rattus norvegicus |
EC Number | Cofactor | Comment | Organism | Structure |
---|---|---|---|---|
6.3.1.2 | ATP | - |
Homo sapiens | |
6.3.1.2 | ATP | - |
Rattus norvegicus |