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Literature summary extracted from

  • Berger, B.J.; Knodel, M.H.
    Characterisation of methionine adenosyltransferase from Mycobacterium smegmatis and M. tuberculosis (2003), BMC Microbiol., 3, 12.
    View publication on PubMedView publication on EuropePMC

Cloned(Commentary)

EC Number Cloned (Comment) Organism
2.5.1.6
-
Mycolicibacterium smegmatis

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.5.1.6 1-methyluric acid 10 mM, 43.4% inhibition Mycolicibacterium smegmatis
2.5.1.6 1-Methylxanthine 10 mM, 35.9% inhibition Mycolicibacterium smegmatis
2.5.1.6 2,6-diaminopurine 10 mM, 29.3% inhibition Mycolicibacterium smegmatis
2.5.1.6 2,6-dichloropurine 10 mM, 35.5% inhibition Mycolicibacterium smegmatis
2.5.1.6 2-amino-6-carboxyethylmercaptopurine 10 mM, 31.9% inhibition Mycolicibacterium smegmatis
2.5.1.6 2-amino-6-chloropurine riboside 10 mM, 17.2% inhibition Mycolicibacterium smegmatis
2.5.1.6 2-amino-6-chloropurine-9-acetic acid 10 mM, 23.5% inhibition Mycolicibacterium smegmatis
2.5.1.6 2-Aminopurine 10 mM, 11.0% inhibition Mycolicibacterium smegmatis
2.5.1.6 2-Hydroxypurine 10 mM, 33.8% inhibition Mycolicibacterium smegmatis
2.5.1.6 3,7-dimethyluric acid 10 mM, 27.9% inhibition Mycolicibacterium smegmatis
2.5.1.6 6-benzyloxypurine 10 mM, 17.7% inhibition Mycolicibacterium smegmatis
2.5.1.6 6-bromopurine 10 mM, 31.4% inhibition Mycolicibacterium smegmatis
2.5.1.6 6-Chloropurine 10 mM, 31.4% inhibition Mycolicibacterium smegmatis
2.5.1.6 6-Chloropurine riboside 10 mM, 17.1% inhibition Mycolicibacterium smegmatis
2.5.1.6 6-Cyanopurine 10 mM, 24.2% inhibition Mycolicibacterium smegmatis
2.5.1.6 6-dimethylallylaminopurine riboside 10 mM, 41.6% inhibition Mycolicibacterium smegmatis
2.5.1.6 6-Dimethylaminopurine 10 mM, 28.0% inhibition Mycolicibacterium smegmatis
2.5.1.6 6-Mercaptopurine 10 mM, 40.1% inhibition Mycolicibacterium smegmatis
2.5.1.6 6-mercaptopurine riboside 10 mM, 30.0% inhibition Mycolicibacterium smegmatis
2.5.1.6 6-propoxypurine 10 mM, 27.9% inhibition Mycolicibacterium smegmatis
2.5.1.6 7-hydroxypropyl theophylline 10 mM, 16.1% inhibition Mycolicibacterium smegmatis
2.5.1.6 7-Methyluric acid 10 mM, 11.4% inhibition Mycolicibacterium smegmatis
2.5.1.6 7-methylxanthine 10 mM, 36.3% inhibition Mycolicibacterium smegmatis
2.5.1.6 8-aza-2,6-diaminopurine 10 mM, 40.0% inhibition Mycolicibacterium smegmatis
2.5.1.6 8-Azaguanine 10 mM, 81.7% inhibition Mycolicibacterium smegmatis
2.5.1.6 8-chlorotheophylline 10 mM, 7.0% inhibition Mycolicibacterium smegmatis
2.5.1.6 alpha-methyl-DL-methionine 10 mM, 18.8% inhibition Mycolicibacterium smegmatis
2.5.1.6 Azathioprine 10 mM, 75.5% inhibition Mycolicibacterium smegmatis
2.5.1.6 cycloleucine 10 mM, 25.8% inhibition Mycolicibacterium smegmatis
2.5.1.6 L-ethioninamide 10 mM, 23.9% inhibition Mycolicibacterium smegmatis
2.5.1.6 L-ethionine 10 mM, 20.4% inhibition Mycolicibacterium smegmatis
2.5.1.6 L-methionine methyl ester 10 mM, 17.7% inhibition Mycolicibacterium smegmatis
2.5.1.6 L-methionine sulfone 10 mM, 9.2% inhibition Mycolicibacterium smegmatis
2.5.1.6 L-methionine sulfoxide 10 mM, 4.0% inhibition Mycolicibacterium smegmatis
2.5.1.6 L-methionine sulfoximine 10 mM, 12.6% inhibition Mycolicibacterium smegmatis
2.5.1.6 L-Penicillamine 10 mM, 15.0% inhibition Mycolicibacterium smegmatis
2.5.1.6 methylthio propionaldehyde 10 mM, 18.4% inhibition Mycolicibacterium smegmatis
2.5.1.6 additional information not inhibitory: (R)-methioninol, 1,3,7-trimethyluric acid, 6-methylpurine Mycolicibacterium smegmatis
2.5.1.6 O-methylguanine 10 mM, 60.3% inhibition Mycolicibacterium smegmatis
2.5.1.6 uric acid 10 mM, 45.6% inhibition Mycolicibacterium smegmatis
2.5.1.6 xanthine 10 mM, 35.4% inhibition Mycolicibacterium smegmatis

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
2.5.1.6 0.076
-
ATP 37°C, pH 8.2 Mycolicibacterium smegmatis
2.5.1.6 0.288
-
L-methionine 37°C, pH 8.2 Mycolicibacterium smegmatis

Organism

EC Number Organism UniProt Comment Textmining
2.5.1.6 Mycolicibacterium smegmatis Q7WYN1
-
-

Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
2.5.1.6 1.3
-
-
Mycolicibacterium smegmatis

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.5.1.6 ATP + L-methionine + H2O
-
Mycolicibacterium smegmatis phosphate + diphosphate + S-adenosyl-L-methionine
-
?

Turnover Number [1/s]

EC Number Turnover Number Minimum [1/s] Turnover Number Maximum [1/s] Substrate Comment Organism Structure
2.5.1.6 0.93
-
L-methionine 37°C, pH 8.2 Mycolicibacterium smegmatis

Ki Value [mM]

EC Number Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
2.5.1.6 3.7
-
Azathioprine 37°C, pH 8.2 Mycolicibacterium smegmatis
2.5.1.6 4.7
-
8-Azaguanine 37°C, pH 8.2 Mycolicibacterium smegmatis