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Literature summary for 7.6.2.2 extracted from

  • Rappa, G.; Lorico, A.; Flavell, R.A.; Sartorelli, A.C.
    Evidence that the multidrug resistance protein (MRP) functions as a Co-transporter of glutathione and natural product toxins (1997), Cancer Res., 57, 5232-5237.
    View publication on PubMed
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Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Mus musculus baseline enzyme expression protects cells from the toxic effects of xenobiotics by effluxing the xenobiotics and GSH from the intracellular compartment into the extracellular medium by a cotransport mechanism ?
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 ?

Organism

Organism UniProt Comment Textmining
Mus musculus
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-
-

Source Tissue

Source Tissue Comment Organism Textmining
embryonic stem cell W9.5 ES cells Mus musculus
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NIH-3T3 cell
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 Mus musculus
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
etoposide/in + ATP + H2O
-
 Mus musculus etoposide/out + ADP + phosphate
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 ?
additional information the enzyme functions as cotransporter of glutathione and natural product toxins Mus musculus ?
-
 ?
additional information baseline enzyme expression protects cells from the toxic effects of xenobiotics by effluxing the xenobiotics and GSH from the intracellular compartment into the extracellular medium by a cotransport mechanism Mus musculus ?
-
 ?