Literature summary for 3.5.4.16 extracted from

Liu, Y.; Baumgardt, S.L.; Fang, J.; Shi, Y.; Qiao, S.; Bosnjak, Z.J.; Vasquez-Vivar, J.; Xia, Z.; Warltier, D.C.; Kersten, J.R.; Ge, Z.D.
Transgenic overexpression of GTP cyclohydrolase 1 in cardiomyocytes ameliorates post-infarction cardiac remodeling (2017), Sci. Rep., 7, 3093 .

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Application

Application	Comment	Organism
medicine	cardiomyocyte GTP cyclohydrolase 1 is a therapeutic target for cardiac remodeling and dysfunction after myocardial infarction	Mus musculus

Organism

Organism	UniProt	Comment	Textmining
Mus musculus	Q05915	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
cardiac muscle fiber	-	Mus musculus	-
heart	cardiac GTP cyclohydrolase 1 is degraded in remodeled hearts after myocardial infarction, concomitant with increases in the thickness of interventricular septum, interstitial fibrosis, and phosphorylated p38 mitogen-activated protein kinase and decreases in left ventricular anterior wall thickness, cardiac contractility, tetrahydrobiopterin, the dimers of nitric oxide synthase, sarcoplasmic reticulum Ca2+ release, and the expression of sarcoplasmic reticulum Ca2+ handling proteins	Mus musculus	-

Synonyms

Synonyms	Comment	Organism
GCH1	-	Mus musculus

General Information

General Information	Comment	Organism
metabolism	cardiac GTP cyclohydrolase 1 is degraded in remodeled hearts after myocardial infarction, concomitant with increases in the thickness of interventricular septum, interstitial fibrosis, and phosphorylated p38 mitogen-activated protein kinase and decreases in left ventricular anterior wall thickness, cardiac contractility, tetrahydrobiopterin, the dimers of nitric oxide synthase, sarcoplasmic reticulum Ca2+ release, and the expression of sarcoplasmic reticulum Ca2+ handling proteins. Transgenic overexpression of GTP cyclohydrolase 1 in cardiomyocytes reduces the thickness of interventricular septum and interstitial fibrosis and increases anterior wall thickness and cardiac contractility after infarction. Overexpression of GTP cyclohydrolase 1 decreases phosphorylated p38 mitogen-activated protein kinase and elevates tetrahydrobiopterin levels, the dimerization and phosphorylation of neuronal nitric oxide synthase, sarcoplasmic reticulum Ca2+ release, and sarcoplasmic reticulum Ca2+ handling proteins in post-infarction remodeled hearts	Mus musculus

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Release 2023.1 (January 2023)