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Literature summary for 3.4.24.B12 extracted from

  • McMahon, M.; Ye, S.; Izzard, L.; Dlugolenski, D.; Tripp, R.A.; Bean, A.G.; McCulloch, D.R.; Stambas, J.
    ADAMTS5 is a critical regulator of virus-specific T cell immunity (2016), PLoS Biol., 14, e1002580 .
    View publication on PubMedView publication on EuropePMC
Search for more literature for 3.4.24.B12

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
aggrecan + H2O Mus musculus
-
 ?
-
 ?
versican + H2O Mus musculus
-
 ?
-
 ?

Organism

Organism UniProt Comment Textmining
Mus musculus P59384
-
-

Source Tissue

Source Tissue Comment Organism Textmining
alveolar macrophage
-
 Mus musculus
-
B cell
-
 Mus musculus
-
culture condition:CD4+ cell
-
 Mus musculus
-
culture condition:CD8+ cell
-
 Mus musculus
-
dendritic cell
-
 Mus musculus
-
interstitial macrophage
-
 Mus musculus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
aggrecan + H2O
-
 Mus musculus ?
-
 ?
versican + H2O
-
 Mus musculus ?
-
 ?

Synonyms

Synonyms Comment Organism
a disintegrin-like and metalloproteinase with thrombospondin-1 motifs 5
-
 Mus musculus
ADAMTS5
-
 Mus musculus

General Information

General Information Comment Organism
malfunction influenza virus infection of enzyme-deficient mice results in delayed virus clearance, compromised T cell migration and immunity and accumulation of versican. Enzyme-deficient mice exhibit increased weight loss and delayed influenza virus clearance following infection Mus musculus
physiological function the enzyme is a critical regulator of virus-specific T cell immunity. Its enzymatic activity plays a key role in the development of influenza-specific immunity. The enzyme cleaves large proteoglycans such as aggrecan, leading to the destruction of cartilage and osteoarthritis Mus musculus