Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
membrane | ECE-1 is a membrane-bound metalloprotease | Homo sapiens | 16020 | - |
nucleus | isozyme ECE-1a co-localizes with nucleolin | Homo sapiens | 5634 | - |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
additional information | ECE-1 is a membrane-bound metalloprotease | Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
big endothelin + H2O | Homo sapiens | ECE-1 is a membrane-bound metalloprotease responsible for production of vasoactive endothelin-1 from inactive big ET-1 | endothelin + ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
isozymes ECE-1a-d | - |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
EAhy 926 cell | expression of isozymes ECE-1a-d | Homo sapiens | - |
additional information | isozyme expression and distribution analysis, overview | Homo sapiens | - |
umbilical vein endothelial cell | primary, expression of isozymes ECE-1a-d | Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
big endothelin + H2O | activation | Homo sapiens | endothelin + ? | - |
? | |
big endothelin + H2O | ECE-1 is a membrane-bound metalloprotease responsible for production of vasoactive endothelin-1 from inactive big ET-1 | Homo sapiens | endothelin + ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
ECE-1 | - |
Homo sapiens |
endothelin-converting enzyme-1 | - |
Homo sapiens |