Cloned (Comment) | Organism |
---|---|
gene MMP7, quantitative real-time PCR enzyme expression analysis | Homo sapiens |
Protein Variants | Comment | Organism |
---|---|---|
additional information | shRNA interfering MMP7 downregulates MMP | Homo sapiens |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
extracellular | - |
Homo sapiens | - |
- |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Zn2+ | a zinc metalloproteinase | Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | P09237 | - |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
epithelium | - |
Homo sapiens | - |
HK-2 cell | - |
Homo sapiens | - |
kidney | - |
Homo sapiens | - |
mesenchyme | - |
Homo sapiens | - |
renal tubule epithelium | - |
Homo sapiens | - |
Synonyms | Comment | Organism |
---|---|---|
Matrix metalloproteinase 7 | - |
Homo sapiens |
MMP7 | - |
Homo sapiens |
Organism | Comment | Expression |
---|---|---|
Homo sapiens | resveratrol inhibits MMP7 expression | down |
General Information | Comment | Organism |
---|---|---|
malfunction | resveratrol attenuates renal injury and fibrosis by inhibiting epithelial-mesenchymal transition (EMT) process which is attributed to the fact that the up-regulated shRNA interfering MMP7 and sirtuin 1 (SIRT1) by resveratrol deacetylates Smad4 and inhibits MMP7 expression. In developing renal fibrosis, tubular epithelial cells in the kidney undergo epithelial-mesenchymal transition (EMT). Resveratrol reverses human kidney 2 (HK-2) cell EMT, renal I/R injury, and renal fibrosis. MMP7 inhibition is responsible for RSV-induced EMT repression | Homo sapiens |
physiological function | matrix metalloproteinase 7 (MMP7) is reported to reduce E-cadherin and induce EMT by upregulation of beta-catenin/lymphoid enhancer-binding factor 1 (LEF1) signaling | Homo sapiens |