Inhibitors | Comment | Organism | Structure |
---|---|---|---|
calpain inhibitor-III | completely inhibited by 0.01 mM | Mus musculus | |
calpain inhibitor-III | completely inhibited by 0.01 mM | Rattus norvegicus |
Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|
75000 | - |
x * 75000, active fragment, SDS-PAGE | Mus musculus |
75000 | - |
x * 75000, active fragment, SDS-PAGE | Rattus norvegicus |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
alpha-spectrin + H2O | Mus musculus | - |
? | - |
? | |
alpha-spectrin + H2O | Rattus norvegicus | - |
? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Mus musculus | - |
- |
- |
Rattus norvegicus | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
cardiomyocyte | - |
Mus musculus | - |
H9c2 cell | - |
Rattus norvegicus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
alpha-spectrin + H2O | - |
Mus musculus | ? | - |
? | |
alpha-spectrin + H2O | - |
Rattus norvegicus | ? | - |
? |
Subunits | Comment | Organism |
---|---|---|
? | x * 75000, active fragment, SDS-PAGE | Mus musculus |
? | x * 75000, active fragment, SDS-PAGE | Rattus norvegicus |
Organism | Comment | Expression |
---|---|---|
Mus musculus | cell infection with Ad-capn1 and significantly elevates the protein level of calpain-1 | up |
Rattus norvegicus | cell infection with Ad-capn1 and significantly elevates the protein level of calpain-1 | up |
General Information | Comment | Organism |
---|---|---|
physiological function | calpain-1 induces endoplasmic reticulum stress and c-Jun N-terminal protein kinase1/2 activation, thereby mediating apoptosis in cardiomyocytes following hypoxia/reoxygenation. Up-regulation of calpain-1 induces increases in caspase-3 activation and DNA fragmentation, indicative of apoptosis | Mus musculus |
physiological function | calpain-1 induces endoplasmic reticulum stress and c-Jun N-terminal protein kinase1/2 activation, thereby mediating apoptosis in cardiomyocytes following hypoxia/reoxygenation. Up-regulation of calpain-1 induces increases in caspase-3 activation and DNA fragmentation, indicative of apoptosis | Rattus norvegicus |