Application | Comment | Organism |
---|---|---|
medicine | cathepsin S activation of PAR-2 may represent a potential therapeutic target for amelioration of ocular surface inflammation in Sjögren's syndrome patients | Homo sapiens |
Cloned (Comment) | Organism |
---|---|
gene CTSS, real-time PCR enzyme expression analysis | Homo sapiens |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
lysosome | - |
Homo sapiens | 5764 | - |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | Homo sapiens | cathepsin S-dependent activation of PAR-2 activation | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | P25774 | - |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
corneal epithelial cell | - |
Homo sapiens | - |
eye | - |
Homo sapiens | - |
HCE-T cell | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | cathepsin S-dependent activation of PAR-2 activation | Homo sapiens | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
CTSS | - |
Homo sapiens |
Organism | Comment | Expression |
---|---|---|
Homo sapiens | CTSS gene expression is increased after cells have been treated with recombinant CTSS for 24 h. CTSS protein expression in cell lysates measured using the human CTSS ELISA kit also reveal that the protein increases after 8 h CTSS treatment | up |
General Information | Comment | Organism |
---|---|---|
malfunction | cathepsin S (CTSS) activity is increased in tears of Sjögren's syndrome patients. This elevated CTSS may contribute to ocular surface inflammation. Cells with reduced PAR-2 expression show reduced ability of chronic CTSS to induce gene expression of pro-inflammatory cytokines and proteases. Acute exposure to heat-inactivated CTSS does not induce pro-inflammatory cytokines | Homo sapiens |
physiological function | cathepsin S alters the expression of pro-inflammatory cytokines and MMP-9, partially through protease-activated receptor-2, in human corneal epithelial cells. Acute CTSS exposure significantly increased HCE-T cell gene and protein expression of interleukin 6 (IL-6), interleukin 8 (IL-8), tumor necrosis factor-alpha (TNF-alpha), and interleukin-1beta (IL-1beta) from 2 to 4 h, while matrix metalloproteinase 9 (MMP-9), CTSS, and protease-activated receptor-2 (PAR-2) are increased by chronic CTSS exposure | Homo sapiens |