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Literature summary for 3.4.21.107 extracted from

  • Chien, J.; Aletti, G.; Baldi, A.; Catalano, V.; Muretto, P.; Keeney, G.L.; Kalli, K.R.; Staub, J.; Ehrmann, M.; Cliby, W.A.; Lee, Y.K.; Bible, K.C.; Hartmann, L.C.; Kaufmann, S.H.; Shridhar, V.
    Serine protease HtrA1 modulates chemotherapy-induced cytotoxicity (2006), J. Clin. Invest., 116, 1994-2004.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 3.4.21.107

Activating Compound

Activating Compound Comment Organism Structure
additional information both cisplatin and paclitaxel treatment upregulates HtrA1 expression resulting in limited autoproteolysis and activation of HtrA1, active HtrA1 induces cell death in a serine protease-dependent manner and activates caspase-3/7 activity, overview Homo sapiens

Cloned(Commentary)

Cloned (Comment) Organism
gene htrA, overexpression of wild-type and mutant enzymes in SKOV3 cells or OV202 cells Homo sapiens

Protein Variants

Protein Variants Comment Organism
additional information downregulation of HtrA1 inovarian cancer attenuates cisplatin- and paclitaxel-induced cytotoxicity, while overexpression of HtrA1 enhances cisplatin- and paclitaxel-induced cytotoxicity Homo sapiens
S328A site-directed mutagenesis, catalytically inactive mutant HtrA1 Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
additional information no inhibition by Z-VAD-FMK, a broad-spectrum caspase inhibitor, nor dominant-negative caspase 9 Homo sapiens

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
35000
-
 x * 35000, recombinant wild-type and mutant enzyme, SDS-PAGE Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Homo sapiens HtrA1 expression is regulated by cisplatin and paclitaxel, and upregulation results in catalytic activation of HtrA1, overview, HtrA1 influences tumor response to chemotherapy by modulating hemotherapy-induced cytotoxicity, HtrA1 in ovarian and gastric cancers may contribute to in vivo chemoresistance, overview ?
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Posttranslational Modification

Posttranslational Modification Comment Organism
proteolytic modification HtrA1 activation by limited autoproteolysis, not of mutant S328A Homo sapiens

Source Tissue

Source Tissue Comment Organism Textmining
gastric cancer cell high HtrA1 expression levels Homo sapiens
-
OV-202 cell low endogenous HtrA1 level Homo sapiens
-
ovary cancer cell high HtrA1 expression levels Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information HtrA1 expression is regulated by cisplatin and paclitaxel, and upregulation results in catalytic activation of HtrA1, overview, HtrA1 influences tumor response to chemotherapy by modulating hemotherapy-induced cytotoxicity, HtrA1 in ovarian and gastric cancers may contribute to in vivo chemoresistance, overview Homo sapiens ?
-
 ?

Subunits

Subunits Comment Organism
? x * 35000, recombinant wild-type and mutant enzyme, SDS-PAGE Homo sapiens

Synonyms

Synonyms Comment Organism
serine protease HtrA1
-
 Homo sapiens