Literature summary for 3.1.1.98 extracted from

Flowers, G.P.; Topczewska, J.M.; Topczewski, J.
A zebrafish Notum homolog specifically blocks the Wnt/beta-catenin signaling pathway (2012), Development, 139, 2416-2425.

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Organism

Organism	UniProt	Comment	Textmining
Danio rerio	C5H5C4	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
blastoderm	expression of Notum1a first appears around the blastoderm margin prior to the onset of gastrulation	Danio rerio	-
central nervous system	at 24 h post fertilization, expression is particularly pronounced in the central nervous system, including the dorsal neural tube and the midbrain-hindbrain boundary	Danio rerio	-
embryo	-	Danio rerio	-
neural plate	Notum1a is expressed in the lateral edges and midline of the posterior neural plate. During segmentation, it is expressed in stripes at the lateral edges and adjacent to the midline of the neural plate	Danio rerio	-

Synonyms

Synonyms	Comment	Organism
Notum 1a	-	Danio rerio

Expression

Organism	Comment	Expression
Danio rerio	Notum1a expression requires Wnt/beta-catenin signaling	up

General Information

General Information	Comment	Organism
physiological function	Notum1a contributes to a self-regulatory loop that restricts Wnt/betA-catenin signaling. Notum 1a does not interact with Glypican 4, an essential component of the Wnt/planar cell polarity pathway, but plays specific role in the developing vertebrate embryo. In cultured cells, Notum1a inhibits Wnt/beta-catenin signaling	Danio rerio

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Release 2023.1 (January 2023)