Application | Comment | Organism |
---|---|---|
medicine | diacylglycerol lipase alpha (DAGLA) may be a key determinant in tumoral progression and might be a therapeutic target in oral squamous cell carcinomas (OSCCs) | Homo sapiens |
Protein Variants | Comment | Organism |
---|---|---|
additional information | generation and cell-cycle analysis of enzyme deficient siDAGLA cells. Overexpression of DAGLA controls cellular proliferation in OSCC cells and clinical samples through cell-cycle progression. DAGLA-positive OSCC is correlated highly with the primary tumoral size. OSCC cells (KOSC-2 and Ho-1-N-1) are injected subcutaneously into the backs of female nude mice. The tumoral volume of the orlistat-treated group is clearly smaller than that of the control group. DAGLA inhibitor orlistat does not affect the body weight of the mice compared with the control group | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
orlistat | - |
Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
1-acyl-2-arachidonoyl-sn-glycerol + H2O | Homo sapiens | - |
2-arachidonoylglycerol + fatty acid | - |
r |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | Q9Y4D2 | - |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
brain | - |
Homo sapiens | - |
Ca9-22 cell | an OSCC cell line | Homo sapiens | - |
HO-1-N-1 cell | an OSCC cell line | Homo sapiens | - |
Ho-1-u-1 cell | an OSCC cell line | Homo sapiens | - |
HSC-2 cell | an OSCC cell line | Homo sapiens | - |
HSC-3 cell | an OSCC cell line | Homo sapiens | - |
HSC-4 cell | an OSCC cell line | Homo sapiens | - |
KOSC-2 cell | an OSCC cell line | Homo sapiens | - |
additional information | real-time quantitative reverse transcription PCR, immunoblotting, and immunohistochemic enzyme analysis, upregulation of DAGLA in OSCC cells | Homo sapiens | - |
oral squamous cell carcinoma cell | primary OSCC cells | Homo sapiens | - |
Sa-3 cell | an OSCC cell line | Homo sapiens | - |
SAS cell | an OSCC cell line | Homo sapiens | - |
spinal cord | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
1-acyl-2-arachidonoyl-sn-glycerol + H2O | - |
Homo sapiens | 2-arachidonoylglycerol + fatty acid | - |
r |
Synonyms | Comment | Organism |
---|---|---|
DAGLA | - |
Homo sapiens |
diacylglycerol lipase alpha | - |
Homo sapiens |
General Information | Comment | Organism |
---|---|---|
malfunction | knockdown models in OSCC-derived cell lines for DAGLA (siDAGLA) and treatment with a lipase inhibitor (orlistat) show several depressed cellular functions, including cellular proliferation and migratory activities through cell-cycle arrest at G1 phase | Homo sapiens |
physiological function | diacylglycerol lipase alpha (DAGLA), which catalyzes the hydrolysis of diacylglycerol to 2-arachidonoylglycerol and free fatty acid, is required for axonal growth during the brain development and for retrograde synaptic signaling at mature synapses. Diacylglycerol lipase alpha promotes tumorigenesis in oral cancer by cell-cycle progression. DAGLA-positive oral squamous cell carcinomas (OSCCs) samples are correlated highly with the primary tumoral size. DAGLA may be a key determinant in tumoral progression and might be a therapeutic target for OSCCs | Homo sapiens |