Inhibitors | Comment | Organism | Structure |
---|---|---|---|
Pentachlorophenol | significantly reduces cell death and aristolactam-DNA adduct levels in HK-2 cells following exposure to aristolochic acid I and N-hydroxyaristolactam I | Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | P50225 | isoform SULT1A1 | - |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
GM00637 cell | - |
Homo sapiens | - |
HK-2 cell | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
3'-phosphoadenylyl sulfate + N-hydroxyaristolactam I | - |
Homo sapiens | adenosine 3',5'-bisphosphate + N-hydroxyaristolactam I sulfate | - |
? |
General Information | Comment | Organism |
---|---|---|
metabolism | silencing of SULT1A1 and 3'-phosphoadenosine-5'-phosphosulfate synthase 2 leads to a significant decrease in aristolactam-DNA levels following exposure to aristolochic acid I. In GM00637 cells exposed to N-hydroxyaristolactam I, suppressing the sulfotransferase pathway leads to a significant decrease in aristolactam-DNA adduct formation | Homo sapiens |