Literature summary for 2.7.6.2 extracted from

Jonus, H.C.; Hanberry, B.S.; Khatu, S.; Kim, J.; Luesch, H.; Dang, L.H.; Bartlett, M.G.; Zastre, J.A.
The adaptive regulation of thiamine pyrophosphokinase-1 facilitates malignant growth during supplemental thiamine conditions (2018), Oncotarget, 9, 35422-35438 .

Search for more literature for 2.7.6.2

Application

Application	Comment	Organism
medicine	TPK1 is post-transcriptionally upregulated in cancer cells following hypoxic exposure. TPK1 expression is also adaptively upregulated following alterations of redox status by chemotherapeutic and antioxidant treatments. Despite upregulation by hypoxia, intracellular TPP levels are reduced. This loss was reversed by treatment with cell-permeable antioxidants and corresponds with reduced ROS production and enhanced cellular proliferation during supplemental thiamine conditions. siRNA-mediated knockdown of TPK1 directly enhances basal ROS levels and reduces tumor cell proliferation	Homo sapiens

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	Q9H3S4	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
Caco-2 cell	-	Homo sapiens	-
HCT-116 cell	-	Homo sapiens	-
HuTu-80 cell	-	Homo sapiens	-
LN-18 cell	-	Homo sapiens	-
MCF-7 cell	-	Homo sapiens	-
MDA-MB-231 cell	-	Homo sapiens	-
U-87MG cell	-	Homo sapiens	-

Synonyms

Synonyms	Comment	Organism
Tpk1	-	Homo sapiens

General Information

General Information	Comment	Organism
physiological function	TPK1 is post-transcriptionally upregulated in cancer cells following hypoxic exposure. TPK1 expression is also adaptively upregulated following alterations of redox status by chemotherapeutic and antioxidant treatments. Despite upregulation by hypoxia, intracellular TPP levels are reduced. This loss was reversed by treatment with cell-permeable antioxidants and corresponds with reduced ROS production and enhanced cellular proliferation during supplemental thiamine conditions. siRNA-mediated knockdown of TPK1 directly enhances basal ROS levels and reduces tumor cell proliferation	Homo sapiens

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Release 2023.1 (January 2023)