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Literature summary for 2.7.2.3 extracted from
- Characterization of filarial phosphoglycerate kinase (2019), Biochimie, 165, 258-266 .
Activating Compound
| Activating Compound | Comment | Organism | Structure |
|---|---|---|---|
| Calmodulin | a significant increase (1.8 times) in enzyme activity is observed in the co-presence of calmodulin (0.001 mM) and CaCl2 (0.01 mM). The enzyme activity remains unaltered in the presence of either calcium or calmodulin alone | Brugia malayi |  |
| Calmodulin | the enzyme is activated up to 85% in the presence of 0.001 mM calmodulin | Setaria cervi | |
Cloned(Commentary)
| Cloned (Comment) | Organism |
|---|---|
- |
Brugia malayi |
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| Ca2+ | 5.0 mM Ca2+ results in 40% inhibition of activity | Setaria cervi | |
| EDTA | - |
Brugia malayi | |
| EDTA | - |
Setaria cervi | |
Metals/Ions
| Metals/Ions | Comment | Organism | Structure |
|---|---|---|---|
| Ca2+ | a significant increase (1.8 times) in enzyme activity is observed in the co-presence of calmodulin (0.001 mM) and CaCl2 (0.01 mM). The enzyme activity remains unaltered in the presence of either calcium or calmodulin alone | Brugia malayi | |
| Ca2+ | the enzyme is activated up to 85% in the presence of 0.01 mM Ca2+ | Setaria cervi | |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| ATP + 3-phospho-D-glycerate | Setaria cervi | - |
ADP + 3-phospho-D-glyceroyl phosphate | - |
? | |
| ATP + 3-phospho-D-glycerate | Brugia malayi | - |
ADP + 3-phospho-D-glyceroyl phosphate | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Brugia malayi | A0A0H5S3P5 | - |
- |
| Brugia malayi | A0A4E9EYJ5 | - |
- |
| Setaria cervi | A0A0M4FXK5 | - |
- |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
| Ni-NTA column chromatography | Brugia malayi |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| adult | - |
Setaria cervi | - |
| adult | - |
Brugia malayi | - |
| microfilarial stage | highest expression | Setaria cervi | - |
| microfilarial stage | highest expression | Brugia malayi | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| ATP + 3-phospho-D-glycerate | - |
Setaria cervi | ADP + 3-phospho-D-glyceroyl phosphate | - |
? | |
| ATP + 3-phospho-D-glycerate | - |
Brugia malayi | ADP + 3-phospho-D-glyceroyl phosphate | - |
? | |
Subunits
| Subunits | Comment | Organism |
|---|---|---|
| ? | x * 45000, SDS-PAGE | Brugia malayi |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| PGK | - |
Setaria cervi |
| PGK | - |
Brugia malayi |
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