Protein Variants | Comment | Organism |
---|---|---|
additional information | knockout of TBRI by shRNA suppression using a lentiviral construct leads to decreased smad2 activtaion and reverses the suppressive effects of TGF-beta on hematopoiesis, overview | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
SD-208 | inhibition of the TBRI kinase inhibits TGF-beta-mediated smad2 activation in hematopoietic progenitors, alleviates anemia, and stimulates hematopoiesis in vivo in bone marrow | Homo sapiens |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Mg2+ | - |
Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + [TGF-beta receptor I] | Homo sapiens | - |
ADP + [TGF-beta receptor I] phosphate | - |
? | |
additional information | Homo sapiens | the TGF-beta pathway is overactivated in myelodysplastic syndrome, MDS, involving ineffective hematopoiesis leading to peripheral cytopenias. Suppression of the TGF-beta signaling leads to in vitro enhancement of hematopoiesis, overview. TBRi inhibition can improve anemia in a model of bone marrow failure, overview | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | P36897 | - |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
bone marrow | CD34+ and stromal cells | Homo sapiens | - |
hematopoietic stem cell | CD34+ | Homo sapiens | - |
HS-5 cell | bone marrow stromal cells | Homo sapiens | - |
K-562 cell | hematopoietic cells | Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + [TGF-beta receptor I] | - |
Homo sapiens | ADP + [TGF-beta receptor I] phosphate | - |
? | |
additional information | the TGF-beta pathway is overactivated in myelodysplastic syndrome, MDS, involving ineffective hematopoiesis leading to peripheral cytopenias. Suppression of the TGF-beta signaling leads to in vitro enhancement of hematopoiesis, overview. TBRi inhibition can improve anemia in a model of bone marrow failure, overview | Homo sapiens | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
alk5 kinase | - |
Homo sapiens |
TBRI | - |
Homo sapiens |
TGF-beta receptor I kinase | - |
Homo sapiens |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
ATP | - |
Homo sapiens |