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Literature summary for 2.7.11.27 extracted from

  • Mottillo, E.P.; Desjardins, E.M.; Fritzen, A.M.; Zou, V.Z.; Crane, J.D.; Yabut, J.M.; Kiens, B.; Erion, D.M.; Lanba, A.; Granneman, J.G.; Talukdar, S.; Steinberg, G.R.
    FGF21 does not require adipocyte AMP-activated protein kinase (AMPK) or the phosphorylation of acetyl-CoA carboxylase (ACC) to mediate improvements in whole-body glucose homeostasis (2017), Mol. Metab., 6, 471-481 .
    View publication on PubMedView publication on EuropePMC
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Activating Compound

Activating Compound Comment Organism Structure
AMP
-
 Mus musculus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + [acetyl-CoA carboxylase] Mus musculus
-
 ADP + [acetyl-CoA carboxylase] phosphate
-
 ?

Organism

Organism UniProt Comment Textmining
Mus musculus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
adipocyte
-
 Mus musculus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + [acetyl-CoA carboxylase]
-
 Mus musculus ADP + [acetyl-CoA carboxylase] phosphate
-
 ?

Synonyms

Synonyms Comment Organism
AMP-activated protein kinase
-
 Mus musculus
AMPK
-
 Mus musculus

General Information

General Information Comment Organism
physiological function the enzyme is a central regulator of the energy status of the cell.The adipocyte enzyme is required for acute brown adipose tissue-mediated thermogenesis, the browning of white adipose tissue in response to beta3-adrenergic stimuli, and protection against the deleterious effects of a high fat diet via the regulation of the mitochondrial quality control pathway (mitophagy). The enzyme is not important for the glucose and lipid-lowering effects of fibroblast growth factor 21 Mus musculus