Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 2.7.11.25 extracted from

  • Zhang, D.; Liu, Y.; Cui, Y.; Cui, S.
    Mitogen-activated protein kinase kinase kinase 8 (MAP3K8) mediates the LH-induced stimulation of progesterone synthesis in the porcine corpus luteum (2019), Reprod. Fertil. Dev., 31, 1444-1456 .
    View publication on PubMed
Search for more literature for 2.7.11.25

Inhibitors

Inhibitors Comment Organism Structure
Tpl2 kinase inhibitor inhibitory at 0.01 mM Sus scrofa

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + ERK1/2 Sus scrofa
-
 ADP + phosphorylated ERK1/2
-
 ?

Organism

Organism UniProt Comment Textmining
Sus scrofa
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
adrenal gland
-
 Sus scrofa
-
corpus luteum highest expression. In pigs, isoform MAP3K8 expression is higher in mature corpus luteums (or those of the mid-luteal phase) than in regressing corpus luteums (late luteal phase) Sus scrofa
-
epididymis lowest expression Sus scrofa
-
hypophysis
-
 Sus scrofa
-
hypothalamus
-
 Sus scrofa
-
luteal cell
-
 Sus scrofa
-
pineal gland
-
 Sus scrofa
-
testis
-
 Sus scrofa
-
uterus
-
 Sus scrofa
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + ERK1/2
-
 Sus scrofa ADP + phosphorylated ERK1/2
-
 ?

Synonyms

Synonyms Comment Organism
MAP3K8
-
 Sus scrofa
mitogen-activated protein kinase kinase kinase 8
-
 Sus scrofa

Expression

Organism Comment Expression
Sus scrofa after 12-24 h treatment of luteal cells with 100 ng/ml LH, isoform MAP3K8 expression is significantly upregulated up

General Information

General Information Comment Organism
physiological function isoform MAP3K8 mediates the LH-induced stimulation of progesterone synthesis through the protein kinase A/mitogen-activated protein kinase signalling pathway in porcine corpus lutem Sus scrofa