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Literature summary for 2.7.11.19 extracted from

  • Yang, W.; Zhang, C.; Li, Y.; Jin, A.; Sun, Y.; Yang, X.; Wang, B.; Guo, W.
    Phosphorylase kinase beta represents a novel prognostic biomarker and inhibits malignant phenotypes of liver cancer cell (2019), Int. J. Biol. Sci., 15, 2596-2606 .
    View publication on PubMedView publication on EuropePMC
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Application

Application Comment Organism
medicine the low expression of enzyme subunit PHKB can serve as an independent indicator for predicting poor prognosis in hepatocellular carcinoma Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + phosphorylase b Homo sapiens
-
 ADP + phosphorylase a
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
HCCLM-3 cell
-
 Homo sapiens
-
HEP-3B cell
-
 Homo sapiens
-
hepatoma cell
-
 Homo sapiens
-
MHCC97-H cell
-
 Homo sapiens
-
SMMC-7721 cell
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + phosphorylase b
-
 Homo sapiens ADP + phosphorylase a
-
 ?

Synonyms

Synonyms Comment Organism
PhK
-
 Homo sapiens
PHKB subunit Homo sapiens
phosphorylase kinase beta subunit Homo sapiens

Expression

Organism Comment Expression
Homo sapiens the expression of subunit PHKB is significantly decreased in hepatocellular carcinoma tissues down

General Information

General Information Comment Organism
physiological function the over (or high) expression of enzyme subunit PHKB greatly hinders hepatocellular carcinoma cell invasion and increases apoptosis rates. The enzyme subunit PHKB inhibits AKT and STAT3 signaling pathway activation in hepatocellular carcinoma Homo sapiens