Inhibitors | Comment | Organism | Structure |
---|---|---|---|
2-(3-methoxybenzyl)-7-(1H-pyrazol-4-yl)phthalazin-1(2H)-one | - |
Homo sapiens | |
3-(3-fluoro-4-methoxybenzyl)-6-(1H-pyrazol-4-yl)quinazolin-4(3H)-one | - |
Homo sapiens | |
3-(3-methoxybenzyl)-6-(1H-pyrazol-4-yl)quinazolin-4(3H)-one | - |
Homo sapiens | |
3-(4-fluoro-3-methoxybenzyl)-6-(1H-pyrazol-4-yl)quinazolin-4(3H)-one | - |
Homo sapiens | |
3-benzyl-6-(1H-pyrazol-4-yl)quinazolin-4(3H)-one | - |
Homo sapiens | |
3-benzyl-6-(1H-pyrazol-5-yl)quinazolin-4(3H)-one | - |
Homo sapiens | |
3-benzyl-6-(pyridin-4-yl)quinazolin-4(3H)-one | - |
Homo sapiens | |
3-benzyl-6-(pyrimidin-5-yl)quinazolin-4(3H)-one | - |
Homo sapiens | |
3-benzyl-7-(1H-pyrazol-4-yl)quinazolin-4(3H)-one | - |
Homo sapiens | |
3-benzyl-7-fluoro-6-(1H-pyrazol-4-yl)quinazolin-4(3H)-one | - |
Homo sapiens | |
3-benzyl-8-fluoro-6-(1H-pyrazol-4-yl)quinazolin-4(3H)-one | - |
Homo sapiens | |
3-[(1R)-1-(3-methoxyphenyl)ethyl]-6-(1H-pyrazol-4-yl)quinazolin-4(3H)-one | - |
Homo sapiens | |
3-[(1S)-1-(3-methoxyphenyl)ethyl]-6-(1H-pyrazol-4-yl)quinazolin-4(3H)-one | - |
Homo sapiens | |
3-[1-(3-methoxyphenyl)-3-(methylamino)propyl]-6-(1H-pyrazol-4-yl)quinazolin-4(3H)-one | - |
Homo sapiens | |
3-[3-(4-fluorophenoxy)benzyl]-6-(1H-pyrazol-4-yl)quinazolin-4(3H)-one | - |
Homo sapiens | |
3-[3-(difluoromethoxy)benzyl]-6-(1H-pyrazol-4-yl)quinazolin-4(3H)-one | - |
Homo sapiens | |
balanol | - |
Homo sapiens | |
CCG-224406 | - |
Homo sapiens | |
GSK180736A | - |
Homo sapiens | |
N-(4-fluorophenyl)-3-[[4-oxo-6-(1H-pyrazol-4-yl)quinazolin-3(4H)-yl]methyl]benzamide | - |
Homo sapiens | |
N-[(2,6-difluorocyclohexa-1,5-dien-1-yl)methyl]-4-[[4-oxo-6-(1H-pyrazol-4-yl)quinazolin-3(4H)-yl]methyl]benzamide | - |
Homo sapiens | |
N-[(2,6-difluorophenyl)methyl]-3-[[4-oxo-6-(1H-pyrazol-4-yl)quinazolin-3(4H)-yl]methyl]benzamide | - |
Homo sapiens | |
N-[(4-fluorophenyl)methyl]-3-[[4-oxo-6-(1H-pyrazol-4-yl)quinazolin-3(4H)-yl]methyl]benzamide | - |
Homo sapiens | |
paroxetine | modest inhibitory activity | Homo sapiens | |
Takeda 103A | - |
Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + [beta-adrenergic receptor] | Homo sapiens | - |
ADP + phospho-[beta-adrenergic receptor] | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | P25098 | - |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
cardiac muscle fiber | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + [beta-adrenergic receptor] | - |
Homo sapiens | ADP + phospho-[beta-adrenergic receptor] | - |
? |
Synonyms | Comment | Organism |
---|---|---|
G protein coupled receptor kinase | - |
Homo sapiens |
G-protein receptor kinase 2 | - |
Homo sapiens |
GRK2 | - |
Homo sapiens |
IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|
0.000006 | - |
pH and temperature not specified in the publication | Homo sapiens | 3-(3-methoxybenzyl)-6-(1H-pyrazol-4-yl)quinazolin-4(3H)-one | |
0.000009 | - |
pH and temperature not specified in the publication | Homo sapiens | N-(4-fluorophenyl)-3-[[4-oxo-6-(1H-pyrazol-4-yl)quinazolin-3(4H)-yl]methyl]benzamide | |
0.00001 | - |
IC50 below 0.00001 mM, pH and temperature not specified in the publication | Homo sapiens | N-[(2,6-difluorophenyl)methyl]-3-[[4-oxo-6-(1H-pyrazol-4-yl)quinazolin-3(4H)-yl]methyl]benzamide | |
0.00001 | - |
IC50 below 0.00001 mM, pH and temperature not specified in the publication | Homo sapiens | N-[(4-fluorophenyl)methyl]-3-[[4-oxo-6-(1H-pyrazol-4-yl)quinazolin-3(4H)-yl]methyl]benzamide | |
0.000012 | - |
pH and temperature not specified in the publication | Homo sapiens | 3-[1-(3-methoxyphenyl)-3-(methylamino)propyl]-6-(1H-pyrazol-4-yl)quinazolin-4(3H)-one | |
0.000013 | - |
pH and temperature not specified in the publication | Homo sapiens | 3-[(1R)-1-(3-methoxyphenyl)ethyl]-6-(1H-pyrazol-4-yl)quinazolin-4(3H)-one | |
0.000018 | - |
pH and temperature not specified in the publication | Homo sapiens | 3-(4-fluoro-3-methoxybenzyl)-6-(1H-pyrazol-4-yl)quinazolin-4(3H)-one | |
0.000019 | - |
pH and temperature not specified in the publication | Homo sapiens | 2-(3-methoxybenzyl)-7-(1H-pyrazol-4-yl)phthalazin-1(2H)-one | |
0.000078 | - |
pH and temperature not specified in the publication | Homo sapiens | 3-[3-(4-fluorophenoxy)benzyl]-6-(1H-pyrazol-4-yl)quinazolin-4(3H)-one | |
0.000095 | - |
pH and temperature not specified in the publication | Homo sapiens | 3-benzyl-6-(1H-pyrazol-4-yl)quinazolin-4(3H)-one | |
0.000206 | - |
pH and temperature not specified in the publication | Homo sapiens | 3-[3-(difluoromethoxy)benzyl]-6-(1H-pyrazol-4-yl)quinazolin-4(3H)-one | |
0.000278 | - |
pH and temperature not specified in the publication | Homo sapiens | 3-benzyl-7-fluoro-6-(1H-pyrazol-4-yl)quinazolin-4(3H)-one | |
0.000472 | - |
pH and temperature not specified in the publication | Homo sapiens | 3-benzyl-8-fluoro-6-(1H-pyrazol-4-yl)quinazolin-4(3H)-one | |
0.00211 | - |
pH and temperature not specified in the publication | Homo sapiens | 3-[(1S)-1-(3-methoxyphenyl)ethyl]-6-(1H-pyrazol-4-yl)quinazolin-4(3H)-one | |
0.00275 | - |
pH and temperature not specified in the publication | Homo sapiens | 3-(3-fluoro-4-methoxybenzyl)-6-(1H-pyrazol-4-yl)quinazolin-4(3H)-one | |
0.0041 | - |
pH and temperature not specified in the publication | Homo sapiens | 3-benzyl-7-(1H-pyrazol-4-yl)quinazolin-4(3H)-one | |
0.02 | - |
pH and temperature not specified in the publication | Homo sapiens | N-[(2,6-difluorocyclohexa-1,5-dien-1-yl)methyl]-4-[[4-oxo-6-(1H-pyrazol-4-yl)quinazolin-3(4H)-yl]methyl]benzamide | |
0.025 | - |
pH and temperature not specified in the publication | Homo sapiens | 3-benzyl-6-(pyridin-4-yl)quinazolin-4(3H)-one | |
0.1 | - |
IC50 above 0.1 mM, pH and temperature not specified in the publication | Homo sapiens | 3-benzyl-6-(1H-pyrazol-5-yl)quinazolin-4(3H)-one | |
0.1 | - |
IC50 above 0.1 mM, pH and temperature not specified in the publication | Homo sapiens | 3-benzyl-6-(pyrimidin-5-yl)quinazolin-4(3H)-one |