Application | Comment | Organism |
---|---|---|
medicine | A12B4C3 enhances the radiosensitivity of human A549 lung carcinoma and MDA-MB-231 breast adenocarcinoma cells by a factor of two | Homo sapiens |
Cloned (Comment) | Organism |
---|---|
- |
Homo sapiens |
- |
Schizosaccharomyces pombe |
- |
Mus musculus |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
2-(1-hydroxyundecyl)-1-(4-nitrophenylamino)-6-phenyl-6,7a-dihydro-1H-pyrrolo[3,4-b]pyridine-5,7(2H,4aH)-dione | A12B4C3 | Homo sapiens | |
2-(1-hydroxyundecyl)-1-(4-nitrophenylamino)-6-phenyl-6,7a-dihydro-1H-pyrrolo[3,4-b]pyridine-5,7(2H,4aH)-dione | A12B4C3 | Mus musculus | |
2-(1-hydroxyundecyl)-1-(4-nitrophenylamino)-6-phenyl-6,7a-dihydro-1H-pyrrolo[3,4-b]pyridine-5,7(2H,4aH)-dione | A12B4C3 | Schizosaccharomyces pombe | |
2-(1-hydroxyundecyl)-1-(4-nitrophenylamino)-6-phenyl-6,7a-dihydro-1H-pyrrolo[3,4-b]pyridine-5,7(2H,4aH)-dione | A12B4C3 | Tequatrovirus T4 | |
2-(hydroxy(3,4,5-trimethoxyphenyl)methyl)-1-(4-nitrophenylamino)-6-phenyl-6,7a-dihydro-1H-pyrrolo[3,4-b]pyridine-5,7(2H,4aH)-dione | A6B4C3 | Homo sapiens | |
2-(hydroxy(phenyl)methyl)-1-(4-nitrophenylamino)-6-phenyl-6,7a-dihydro-1H-pyrrolo[3,4-b]pyridine-5,7(2H,4aH)-dione | A1B4C3 | Homo sapiens | |
2-(hydroxy(thiophen-2-yl)methyl)-6-methyl-1-(phenylamino)-6,7a-dihydro-1H-pyrrolo[3,4-b]pyridine-5,7(2H,4aH)-dione | A39B1C2 | Homo sapiens | |
tert-butyl 2-(1-hydroxy-2,2-diphenylethyl)-6-methyl-5,7-dioxo-2,4a,5,6,7,7a-hexahydro-1H-pyrrolo[3,4-b]pyridine-1yl-carbamate | A26B11C2 | Homo sapiens |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Mg2+ | - |
Homo sapiens | |
Mg2+ | - |
Schizosaccharomyces pombe | |
Mg2+ | - |
Tequatrovirus T4 | |
Mg2+ | - |
Mus musculus |
Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|
57100 | - |
- |
Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + 5'-dephospho-DNA | Homo sapiens | - |
ADP + 5'-phospho-DNA | - |
r | |
ATP + 5'-dephospho-DNA | Schizosaccharomyces pombe | - |
ADP + 5'-phospho-DNA | - |
r | |
ATP + 5'-dephospho-DNA | Tequatrovirus T4 | - |
ADP + 5'-phospho-DNA | - |
r | |
ATP + 5'-dephospho-DNA | Mus musculus | - |
ADP + 5'-phospho-DNA | - |
r |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Mus musculus | Q9JLV6 | - |
- |
Schizosaccharomyces pombe | - |
- |
- |
Tequatrovirus T4 | - |
- |
- |
Purification (Comment) | Organism |
---|---|
- |
Homo sapiens |
- |
Schizosaccharomyces pombe |
- |
Mus musculus |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
A-549 cell | - |
Homo sapiens | - |
MDA-MB-231 cell | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + 5'-dephospho-DNA | - |
Homo sapiens | ADP + 5'-phospho-DNA | - |
r | |
ATP + 5'-dephospho-DNA | - |
Schizosaccharomyces pombe | ADP + 5'-phospho-DNA | - |
r | |
ATP + 5'-dephospho-DNA | - |
Tequatrovirus T4 | ADP + 5'-phospho-DNA | - |
r | |
ATP + 5'-dephospho-DNA | - |
Mus musculus | ADP + 5'-phospho-DNA | - |
r |
Synonyms | Comment | Organism |
---|---|---|
hPNKP | - |
Homo sapiens |
mPNKP | - |
Mus musculus |
PNKP | - |
Homo sapiens |
PNKP | - |
Schizosaccharomyces pombe |
PNKP | - |
Tequatrovirus T4 |
PNKP | - |
Mus musculus |
polynucleotide kinase/phosphatase | - |
Homo sapiens |
polynucleotide kinase/phosphatase | - |
Schizosaccharomyces pombe |
polynucleotide kinase/phosphatase | - |
Tequatrovirus T4 |
polynucleotide kinase/phosphatase | - |
Mus musculus |
T4 PNK | - |
Tequatrovirus T4 |
Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|
37 | - |
activity assay | Homo sapiens |
37 | - |
activity assay | Schizosaccharomyces pombe |
37 | - |
activity assay | Tequatrovirus T4 |
37 | - |
activity assay | Mus musculus |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
7.4 | - |
activity assay | Homo sapiens |
7.4 | - |
activity assay | Schizosaccharomyces pombe |
7.4 | - |
activity assay | Tequatrovirus T4 |
7.4 | - |
activity assay | Mus musculus |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
ATP | - |
Homo sapiens | |
ATP | - |
Schizosaccharomyces pombe | |
ATP | - |
Tequatrovirus T4 | |
ATP | - |
Mus musculus |
IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|
0.00006 | - |
- |
Homo sapiens | 2-(1-hydroxyundecyl)-1-(4-nitrophenylamino)-6-phenyl-6,7a-dihydro-1H-pyrrolo[3,4-b]pyridine-5,7(2H,4aH)-dione |