Inhibitors | Comment | Organism | Structure |
---|---|---|---|
(1'R)-2'-acetyl-N-(2-fluorophenyl)-1'-(hydroxymethyl)-7'-methoxy-1',2',3',9'-tetrahydrospiro[piperidine-4,4'-pyrido[3,4-b]indole]-1-carboxamide | BRD73842 | Plasmodium falciparum | |
(1R)-3-[3-[8-(pyridin-4-yl)-1,5-naphthyridin-2-yl]benzene-1-sulfonyl]cyclopentan-1-ol | - |
Plasmodium falciparum | |
(3-aminopyrrolidin-1-yl)(4-[5-amino-6-[6-(trifluoromethyl)pyridin-3-yl]pyrazin-2-yl]phenyl)methanone | - |
Plasmodium falciparum | |
(4-[3-[4-(methanesulfonyl)phenyl]imidazo[1,2-b]pyridazin-6-yl]phenyl)(piperazin-1-yl)methanone | - |
Plasmodium falciparum | |
(4-[5-amino-6-[4-(trifluoromethyl)phenyl]pyrazin-2-yl]phenyl)(3-hydroxypyrrolidin-1-yl)methanone | - |
Plasmodium falciparum | |
(4-[5-amino-6-[4-(trifluoromethyl)phenyl]pyrazin-2-yl]phenyl)(piperazin-1-yl)methanone | - |
Plasmodium falciparum | |
(4-[5-amino-6-[4-(trifluoromethyl)phenyl]pyrazin-2-yl]phenyl)[(3R)-3-hydroxypyrrolidin-1-yl]methanone | - |
Plasmodium falciparum | |
(4-[5-amino-6-[4-(trifluoromethyl)phenyl]pyrazin-2-yl]phenyl)[(3S)-3-hydroxypyrrolidin-1-yl]methanone | - |
Plasmodium falciparum | |
(4-[5-amino-6-[6-(trifluoromethyl)pyridin-3-yl]pyrazin-2-yl]phenyl)(piperazin-1-yl)methanone | - |
Plasmodium falciparum | |
(4-[6-[3-(methanesulfonyl)phenyl]imidazo[1,2-b]pyridazin-3-yl]phenyl)(piperazin-1-yl)methanone | - |
Plasmodium falciparum | |
2-ethoxy-6'-methoxy-5-[4-(methylsulfonyl)phenyl]-3,3'-bipyridine | - |
Plasmodium falciparum | |
2-iodo-6'-methoxy-5-[4-(methylsulfonyl)phenyl]-3,3'-bipyridine | - |
Plasmodium falciparum | |
2-[3-(phenylsulfanyl)phenyl]-8-(pyridin-4-yl)-1,5-naphthyridine | - |
Plasmodium falciparum | |
2-[8-(pyridin-4-yl)-1,5-naphthyridin-2-yl]benzenesulfonamide | - |
Plasmodium falciparum | |
2-[[7-(3,4-dimethoxyphenyl)quinoxalin-2-yl]amino]-N-methylacetamide | BQR695 | Plasmodium falciparum | |
3-(1-methyl-1H-benzimidazol-5-yl)-6-[3-(propane-2-sulfonyl)phenyl]imidazo[1,2-b]pyridazine | - |
Plasmodium falciparum | |
3-(6-methoxypyridin-3-yl)-5-[4-(methylsulfonyl)-2-(trifluoromethyl)phenyl]pyrazin-2-amine | - |
Plasmodium falciparum | |
3-(6-methoxypyridin-3-yl)-5-[4-(methylsulfonyl)phenyl]pyrazin-2-amine | - |
Plasmodium falciparum | |
3-(6-methoxypyridin-3-yl)-5-[4-(trifluoromethoxy)phenyl]pyrazin-2-amine | - |
Plasmodium falciparum | |
3-[4-(methylsulfonyl)phenyl]-6-[2-(trifluoromethyl)pyridin-4-yl]imidazo[1,2-b]pyridazine | - |
Plasmodium falciparum | |
3-[4-(methylsulfonyl)phenyl]-6-[3-(trifluoromethyl)phenyl]imidazo[1,2-b]pyridazine | - |
Plasmodium falciparum | |
3-[8-(4-methylpiperazin-1-yl)-1,5-naphthyridin-2-yl]benzenesulfonamide | - |
Plasmodium falciparum | |
3-[8-(pyridin-4-yl)-1,5-naphthyridin-2-yl]benzenesulfonamide | - |
Plasmodium falciparum | |
4-[5-amino-6-[6-(trifluoromethyl)pyridin-3-yl]pyrazin-2-yl]benzoic acid | - |
Plasmodium falciparum | |
4-[8-(pyridin-4-yl)-1,5-naphthyridin-2-yl]benzenesulfonamide | - |
Plasmodium falciparum | |
5-[4-(methylsulfonyl)phenyl]-3-[6-(trifluoromethyl)pyridin-3-yl]pyrazin-2-amine | - |
Plasmodium falciparum | |
5-[4-(methylsulfonyl)phenyl]-6'-(trifluoromethyl)-3,3'-bipyridin-2-amine | MMV390048 | Plasmodium falciparum | |
6-(3-methylphenyl)-3-(6-methylpyridin-3-yl)imidazo[1,2-b]pyridazine | - |
Plasmodium falciparum | |
6-[3-(methylsulfonyl)phenyl]-3-[4-(methylsulfonyl)phenyl]imidazo[1,2-a]pyridine | - |
Plasmodium falciparum | |
6-[3-(methylsulfonyl)phenyl]-3-[4-(methylsulfonyl)phenyl]imidazo[1,2-a]pyrimidine | - |
Plasmodium falciparum | |
6-[3-(methylsulfonyl)phenyl]-3-[4-(methylsulfonyl)phenyl]imidazo[1,2-b]pyridazine | - |
Plasmodium falciparum | |
6-[4-(cyclopropylsulfonyl)phenyl]-3-[4-(methylsulfonyl)phenyl]imidazo[1,2-b]pyridazine | - |
Plasmodium falciparum | |
N-(4-chlorophenyl)-N-methyl-3-[4-(methylcarbamoyl)phenyl]imidazo[1,2-a]pyrazine-6-carboxamide | KDU691 | Plasmodium falciparum | |
N-(4-cyanophenyl)-N-methyl-3-[4-(trifluoromethyl)phenyl]imidazo[1,2-a]pyrazine-6-carboxamide | KAI407 | Plasmodium falciparum | |
N-cyclopropyl-8-(pyridin-4-yl)-1,5-naphthyridin-2-amine | - |
Plasmodium falciparum | |
N-[3-[8-(pyridin-4-yl)-1,5-naphthyridin-2-yl]phenyl]methanesulfonamide | - |
Plasmodium falciparum | |
[(3R)-3-aminopyrrolidin-1-yl](4-[5-amino-6-[4-(trifluoromethyl)phenyl]pyrazin-2-yl]phenyl)methanone | - |
Plasmodium falciparum | |
[(3S)-3-aminopyrrolidin-1-yl](4-[5-amino-6-[4-(trifluoromethyl)phenyl]pyrazin-2-yl]phenyl)methanone | - |
Plasmodium falciparum |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + 1-phosphatidyl-1D-myo-inositol | Plasmodium falciparum | - |
ADP + 1-phosphatidyl-1D-myo-inositol 4-phosphate | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Plasmodium falciparum | - |
- |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + 1-phosphatidyl-1D-myo-inositol | - |
Plasmodium falciparum | ADP + 1-phosphatidyl-1D-myo-inositol 4-phosphate | - |
? |
Synonyms | Comment | Organism |
---|---|---|
phosphatidylinositol 4-kinase | - |
Plasmodium falciparum |
PI4K | - |
Plasmodium falciparum |
IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|
0.0000015 | - |
pH and temperature not specified in the publication | Plasmodium falciparum | N-(4-chlorophenyl)-N-methyl-3-[4-(methylcarbamoyl)phenyl]imidazo[1,2-a]pyrazine-6-carboxamide | |
0.0000034 | - |
pH and temperature not specified in the publication | Plasmodium falciparum | 5-[4-(methylsulfonyl)phenyl]-6'-(trifluoromethyl)-3,3'-bipyridin-2-amine | |
0.0000035 | - |
pH and temperature not specified in the publication | Plasmodium falciparum | 2-[[7-(3,4-dimethoxyphenyl)quinoxalin-2-yl]amino]-N-methylacetamide | |
0.000021 | - |
pH and temperature not specified in the publication | Plasmodium falciparum | (1'R)-2'-acetyl-N-(2-fluorophenyl)-1'-(hydroxymethyl)-7'-methoxy-1',2',3',9'-tetrahydrospiro[piperidine-4,4'-pyrido[3,4-b]indole]-1-carboxamide | |
0.000023 | - |
pH and temperature not specified in the publication | Plasmodium falciparum | (4-[5-amino-6-[4-(trifluoromethyl)phenyl]pyrazin-2-yl]phenyl)(piperazin-1-yl)methanone | |
0.00012 | - |
pH and temperature not specified in the publication | Plasmodium falciparum | N-(4-cyanophenyl)-N-methyl-3-[4-(trifluoromethyl)phenyl]imidazo[1,2-a]pyrazine-6-carboxamide |