Literature summary for 2.7.1.3 extracted from

Gao, W.; Li, N.; Li, Z.; Xu, J.; Su, C.
Ketohexokinase is involved in fructose utilization and promotes tumor progression in glioma (2018), Biochem. Biophys. Res. Commun., 503, 1298-1306 .

Search for more literature for 2.7.1.3

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	P50053	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
brain	expressed at significantly higher level in glioma tissues than in non-tumor brain	Homo sapiens	-
glioma cell	expressed at significantly higher level in glioma tissues than in non-tumor brain	Homo sapiens	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
ATP + D-fructose	-	Homo sapiens	ADP + D-fructose 1-phosphate	-	?

Synonyms

Synonyms	Comment	Organism
KHK	-	Homo sapiens

General Information

General Information	Comment	Organism
malfunction	functionally, knockdown of ketohexokinase can significantly inhibit cell proliferation and migration of glioma cells in fructose medium	Homo sapiens
metabolism	ketohexokinase overexpression is significantly correlated with tumor malignancy and poor survival of glioma patients	Homo sapiens
metabolism	key enzyme involved in fructose catabolism	Homo sapiens

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Release 2023.1 (January 2023)