Organism | UniProt | Comment | Textmining |
---|---|---|---|
Rattus norvegicus | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
ganglion | dorsal root ganglion | Rattus norvegicus | - |
neuron | peripheral neuron | Rattus norvegicus | - |
PC-12 cell | pheochromocytoma-derived cell | Rattus norvegicus | - |
General Information | Comment | Organism |
---|---|---|
physiological function | cystathionine beta-synthase, cysteine aminotransferase, and mercaptopyruvate sulfurtransferase, but not cystathionine gamma-lyase, are expressed in PC12 cells and the dorsal root ganglion, and appreciable amounts of H2S are produced from L-cysteine in the presence of alpha-ketoglutarate, together with dithiothreitol. The production of H2S is inhibited by cysteine aminotransferase inhibitor aminooxyacetic acid, and competitive cysteine aminotransferase substrates L-aspartate and oxaloacetate. The amount of H2S produced by cysteine aminotransferase/mercaptopyruvate sulfurtransferase at pH 8.0, a physiological mitochondrial matrix pH, is comparable to that produced by cystathionine beta-synthase and cystathionine beta-synthase in the liver and the brain, respectively | Rattus norvegicus |