Cloned (Comment) | Organism |
---|---|
cea S gene of the gene cluster for clavulanic acid biosynthesis, genomic organization | Streptomyces clavuligerus |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Mg2+ | requirement | Streptomyces clavuligerus |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
D-glyceraldehyde 3-phosphate + L-arginine | Streptomyces clavuligerus | first enzyme in the clavulanic acid biosynthetic pathway, which is a beta-lactamase inhibitor | N2-(2-carboxyethyl)-L-arginine + phosphate | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Streptomyces clavuligerus | - |
- |
- |
Purification (Comment) | Organism |
---|---|
- |
Streptomyces clavuligerus |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
D-glyceraldehyde 3-phosphate + L-arginine | first enzyme in the clavulanic acid biosynthetic pathway, which is a beta-lactamase inhibitor | Streptomyces clavuligerus | N2-(2-carboxyethyl)-L-arginine + phosphate | - |
? | |
D-glyceraldehyde 3-phosphate + L-arginine | CEA synthetase condensates glyceraldehyde 3-phosphate and arginine forming an N-C bond | Streptomyces clavuligerus | N2-(2-carboxyethyl)-L-arginine + phosphate | - |
? | |
additional information | not: pyruvic acid | Streptomyces clavuligerus | ? | - |
? |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
ATP | requirement | Streptomyces clavuligerus | |
thiamine diphosphate | cofactor, requirement | Streptomyces clavuligerus |