Application | Comment | Organism |
---|---|---|
medicine | prime target for development of anticancer therapeutics | Homo sapiens |
Cloned (Comment) | Organism |
---|---|
- |
Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
(+)-6-(camphorquinone-10-sulfonamido)-hexanoic acid | - |
Homo sapiens | |
(-)-6-(camphorquinone-10-sulfonamido)-hexanoic acid | - |
Homo sapiens | |
2-oxododecanal | - |
Homo sapiens | |
4,4-(biphenyldiglyoxaldehyde) | - |
Homo sapiens | |
5,9,13-trimethyl-8,12-tetradecadiene-2,3-dione | 0.093 mM causes a 94% reduction in enzyme activity after 30 min | Homo sapiens | |
5,9-dimethyl-8-decene-2,3-dione | 0.017 mM causes a 62% reduction in enzyme activity after 30 min | Homo sapiens | |
dehydrascorbic acid 6-palmitate | - |
Homo sapiens | |
additional information | higher concentrations of the alpha-dicarbonyl compound results in more rapid and more extensive inactivation | Homo sapiens | |
Phenylglyoxal | - |
Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
farnesyl diphosphate + protein-cysteine | Homo sapiens | process required for the transforming activity of oncogenic variants of Ras, making enzyme a prime target for anticancer therapeutics | S-farnesyl protein + diphosphate | - |
? | |
farnesyl diphosphate + protein-cysteine | Homo sapiens | process necessary for the subcellular localisation of substrate to the plasma membrane | S-farnesyl protein + diphosphate | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
farnesyl diphosphate + protein-cysteine | - |
Homo sapiens | diphosphate + S-farnesyl protein | - |
? | |
farnesyl diphosphate + protein-cysteine | process required for the transforming activity of oncogenic variants of Ras, making enzyme a prime target for anticancer therapeutics | Homo sapiens | S-farnesyl protein + diphosphate | - |
? | |
farnesyl diphosphate + protein-cysteine | process necessary for the subcellular localisation of substrate to the plasma membrane | Homo sapiens | S-farnesyl protein + diphosphate | - |
? |