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Literature summary for 2.5.1.22 extracted from
- Myosin Va and spermine synthase partners in exosome transport (2019), Biosci. Rep., 39, BSR20190326 .
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| cytoplasm | - |
Homo sapiens | 5737 | - |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | P52788 | - |
- |
Expression
| Organism | Comment | Expression |
|---|---|---|
| Homo sapiens | knockdown of the MYO5A gene reduces the expression of mRNA coding for spermine synthase. The amount of this transcript is also reduced in cells derived from a patient with Griscelli syndrome type 1. This suggests that, in addition to a direct physical interaction between the two proteins, myosin Va also modulates the transcription of the spermine synthase gene | down |
General Information
| General Information | Comment | Organism |
|---|---|---|
| malfunction | mutations in the spermine synthase gene are associated with Snyder Robinson mental retardation syndrome | Homo sapiens |
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Release 2023.1 (January 2023)
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