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Literature summary for 2.5.1.18 extracted from

  • Temel, Y.; Kocyigit, U.M.; Taysi, M.S.; Goekalp, F.; Guerdere, M.B.; Budak, Y.; Ceylan, M.; Guelcin, I.; Ciftci, M.
    Purification of glutathione S-transferase enzyme from quail liver tissue and inhibition effects of (3aR,4S,7R,7aS)-2-(4-((E)-3-(aryl)acryloyl)phenyl)-3a,4,7,7a-tetrahydro-1H-4,7-methanoisoindole-1,3(2H)-dione derivatives on the enzyme activity (2018), J. Biochem. Mol. Toxicol., 32, e22034 .
    View publication on PubMed
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Inhibitors

Inhibitors Comment Organism Structure
2-[4-[(2E)-3-(2-bromophenyl)prop-2-enoyl]phenyl]-3a,4,7,7a-tetrahydro-1H-4,7-methanoisoindole-1,3(2H)-dione noncompetitive inhibition Coturnix sp.
2-[4-[(2E)-3-(2-chlorophenyl)prop-2-enoyl]phenyl]-3a,4,7,7a-tetrahydro-1H-4,7-methanoisoindole-1,3(2H)-dione noncompetitive inhibition Coturnix sp.
2-[4-[(2E)-3-(3-bromophenyl)prop-2-enoyl]phenyl]-3a,4,7,7a-tetrahydro-1H-4,7-methanoisoindole-1,3(2H)-dione
-
 Coturnix sp.
2-[4-[(2E)-3-(3-chlorophenyl)prop-2-enoyl]phenyl]-3a,4,7,7a-tetrahydro-1H-4,7-methanoisoindole-1,3(2H)-dione
-
 Coturnix sp.
2-[4-[(2E)-3-(4-bromophenyl)prop-2-enoyl]phenyl]-3a,4,7,7a-tetrahydro-1H-4,7-methanoisoindole-1,3(2H)-dione competitive inhibition Coturnix sp.
2-[4-[(2E)-3-(4-chlorophenyl)prop-2-enoyl]phenyl]-3a,4,7,7a-tetrahydro-1H-4,7-methanoisoindole-1,3(2H)-dione noncompetitive inhibition Coturnix sp.
2-[4-[(2E)-3-(4-methylphenyl)prop-2-enoyl]phenyl]-3a,4,7,7a-tetrahydro-1H-4,7-methanoisoindole-1,3(2H)-dione noncompetitive inhibition Coturnix sp.

Organism

Organism UniProt Comment Textmining
Coturnix sp.
-
 Quail
-

Purification (Commentary)

Purification (Comment) Organism
GSH-agarose column chromatography and Superdex S200 gel filtration Coturnix sp.

Source Tissue

Source Tissue Comment Organism Textmining
liver
-
 Coturnix sp.
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
glutathione + 1-chloro-2,4-dinitrobenzene
-
 Coturnix sp. chloride + 2,4-dinitrophenyl-glutathione
-
 ?

Synonyms

Synonyms Comment Organism
glutathione S-transferase
-
 Coturnix sp.
GST
-
 Coturnix sp.

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
0.00304
-
 2-[4-[(2E)-3-(4-bromophenyl)prop-2-enoyl]phenyl]-3a,4,7,7a-tetrahydro-1H-4,7-methanoisoindole-1,3(2H)-dione at pH 6.5, temperature not specified in the publication Coturnix sp.
0.0186
-
 2-[4-[(2E)-3-(2-chlorophenyl)prop-2-enoyl]phenyl]-3a,4,7,7a-tetrahydro-1H-4,7-methanoisoindole-1,3(2H)-dione at pH 6.5, temperature not specified in the publication Coturnix sp.
0.02435
-
 2-[4-[(2E)-3-(4-methylphenyl)prop-2-enoyl]phenyl]-3a,4,7,7a-tetrahydro-1H-4,7-methanoisoindole-1,3(2H)-dione at pH 6.5, temperature not specified in the publication Coturnix sp.
0.02854
-
 2-[4-[(2E)-3-(2-bromophenyl)prop-2-enoyl]phenyl]-3a,4,7,7a-tetrahydro-1H-4,7-methanoisoindole-1,3(2H)-dione at pH 6.5, temperature not specified in the publication Coturnix sp.
0.1315
-
 2-[4-[(2E)-3-(4-chlorophenyl)prop-2-enoyl]phenyl]-3a,4,7,7a-tetrahydro-1H-4,7-methanoisoindole-1,3(2H)-dione at pH 6.5, temperature not specified in the publication Coturnix sp.

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.01
-
 at pH 6.5, temperature not specified in the publication Coturnix sp. 2-[4-[(2E)-3-(4-bromophenyl)prop-2-enoyl]phenyl]-3a,4,7,7a-tetrahydro-1H-4,7-methanoisoindole-1,3(2H)-dione
0.023
-
 at pH 6.5, temperature not specified in the publication Coturnix sp. 2-[4-[(2E)-3-(2-chlorophenyl)prop-2-enoyl]phenyl]-3a,4,7,7a-tetrahydro-1H-4,7-methanoisoindole-1,3(2H)-dione
0.02875
-
 at pH 6.5, temperature not specified in the publication Coturnix sp. 2-[4-[(2E)-3-(4-methylphenyl)prop-2-enoyl]phenyl]-3a,4,7,7a-tetrahydro-1H-4,7-methanoisoindole-1,3(2H)-dione
0.1155
-
 at pH 6.5, temperature not specified in the publication Coturnix sp. 2-[4-[(2E)-3-(4-chlorophenyl)prop-2-enoyl]phenyl]-3a,4,7,7a-tetrahydro-1H-4,7-methanoisoindole-1,3(2H)-dione
0.1575
-
 at pH 6.5, temperature not specified in the publication Coturnix sp. 2-[4-[(2E)-3-(2-bromophenyl)prop-2-enoyl]phenyl]-3a,4,7,7a-tetrahydro-1H-4,7-methanoisoindole-1,3(2H)-dione