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Literature summary for 2.5.1.18 extracted from

  • Uno, Y.; Uehara, S.; Tanaka, S.; Murayama, N.; Yamazaki, H.
    Systematic characterization of glutathione S-transferases in common marmosets (2020), Biochem. Pharmacol., 174, 113835 .
    View publication on PubMed
Search for more literature for 2.5.1.18

Cloned(Commentary)

Cloned (Comment) Organism
expressed in Escherichia coli BL21 cells Callithrix jacchus

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.009
-
 1-iodohexane isoform GSTM5, at pH 7.4 and 25°C Callithrix jacchus
0.009
-
 1-iodohexane isoform GSTT1, at pH 7.4 and 25°C Callithrix jacchus
0.021
-
 1-iodohexane isoform GSTM4, at pH 7.4 and 25°C Callithrix jacchus
0.022
-
 1-iodohexane isoform GSTM2, at pH 7.4 and 25°C Callithrix jacchus
0.026
-
 1-iodohexane isoform GSTM3, at pH 7.4 and 25°C Callithrix jacchus
0.064
-
 styrene 7,8-oxide isoform GSTM2, at pH 7.4 and 25°C Callithrix jacchus
0.09
-
 styrene 7,8-oxide isoform GSTM5, at pH 7.4 and 25°C Callithrix jacchus
0.11
-
 styrene 7,8-oxide isoform GSTM3, at pH 7.4 and 25°C Callithrix jacchus
0.16
-
 styrene 7,8-oxide isoform GSTT1, at pH 7.4 and 25°C Callithrix jacchus
0.183
-
 styrene 7,8-oxide isoform GSTT4, at pH 7.4 and 25°C Callithrix jacchus
0.365
-
 styrene 7,8-oxide isoform GSTM4, at pH 7.4 and 25°C Callithrix jacchus

Localization

Localization Comment Organism GeneOntology No. Textmining
cytosol
-
 Callithrix jacchus 5829
-

Organism

Organism UniProt Comment Textmining
Callithrix jacchus
-
 common marmoset
-

Source Tissue

Source Tissue Comment Organism Textmining
brain isoform GSTA4 mRNA is expressed most abundantly in brain Callithrix jacchus
-
kidney isoform GSTO2 mRNA is expressed most abundantly in kidney Callithrix jacchus
-
liver isoforms GSTA1, GSTA3, GSTA4L, GSTK1, GSTT1, GSTZ1, and MGST1 mRNAs are expressed most abundantly in liver Callithrix jacchus
-
lung isoforms GSTM4, GSTO1, and GSTP1 mRNAs are expressed most abundantly in lung Callithrix jacchus
-
small intestine isoforms GSTM2, GSTM3, GSTM5, GSTS1, MGST2, and MGST3 mRNAs are expressed most abundantly in small intestine Callithrix jacchus
-
testis expression of isoform GSTT4 and GSTT4L mRNAs is detected only in testis Callithrix jacchus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
glutathione + 1,2-epoxy-3-(4-nitrophenoxy)propane
-
 Callithrix jacchus ?
-
 ?
glutathione + 1-chloro-2,4-dinitrobenzene
-
 Callithrix jacchus chloride + 2,4-dinitrophenyl-glutathione
-
 ?
glutathione + 1-iodohexane highest affinity substrate for isoforms GSTT1 and GSTM5 Callithrix jacchus iodide + hexyl-glutathione
-
 ?
glutathione + styrene 7,8-oxide highest affinity substrate for isoforms GSTM2 and GSTM5 Callithrix jacchus ?
-
 ?

Synonyms

Synonyms Comment Organism
glutathione S-transferase
-
 Callithrix jacchus
GST
-
 Callithrix jacchus
GSTA1 isoform Callithrix jacchus
GSTA3 isoform Callithrix jacchus
GSTA4 isoform Callithrix jacchus
GSTA4L isoform Callithrix jacchus
GSTK1 isoform Callithrix jacchus
GSTM2 isoform Callithrix jacchus
GSTM3 isoform Callithrix jacchus
GSTM4 isoform Callithrix jacchus
GSTM5 isoform Callithrix jacchus
GSTO1 isoform Callithrix jacchus
GSTO2 isoform Callithrix jacchus
GSTP1 isoform Callithrix jacchus
GSTT1 isoform Callithrix jacchus
GSTT4 isoform Callithrix jacchus
GSTT4L isoform Callithrix jacchus
Gstz1 isoform Callithrix jacchus
MGST1 isoform Callithrix jacchus
MGST2 isoform Callithrix jacchus
MGST3 isoform Callithrix jacchus

Turnover Number [1/s]

Turnover Number Minimum [1/s] Turnover Number Maximum [1/s] Substrate Comment Organism Structure
0.5
-
 1-iodohexane isoform GSTM2, at pH 7.4 and 25°C Callithrix jacchus
0.55
-
 1-iodohexane isoform GSTM4, at pH 7.4 and 25°C Callithrix jacchus
0.62
-
 1-iodohexane isoform GSTM3, at pH 7.4 and 25°C Callithrix jacchus
0.8
-
 1-iodohexane isoform GSTM5, at pH 7.4 and 25°C Callithrix jacchus
1.1
-
 1-iodohexane isoform GSTT1, at pH 7.4 and 25°C Callithrix jacchus
1.78
-
 styrene 7,8-oxide isoform GSTT4, at pH 7.4 and 25°C Callithrix jacchus
2.22
-
 styrene 7,8-oxide isoform GSTT1, at pH 7.4 and 25°C Callithrix jacchus
2.4
-
 styrene 7,8-oxide isoform GSTM2, at pH 7.4 and 25°C Callithrix jacchus
2.4
-
 styrene 7,8-oxide isoform GSTM3, at pH 7.4 and 25°C Callithrix jacchus
3.13
-
 styrene 7,8-oxide isoform GSTM4, at pH 7.4 and 25°C Callithrix jacchus
4.12
-
 styrene 7,8-oxide isoform GSTM5, at pH 7.4 and 25°C Callithrix jacchus

kcat/KM [mM/s]

kcat/KM Value [1/mMs-1] kcat/KM Value Maximum [1/mMs-1] Substrate Comment Organism Structure
8.3
-
 styrene 7,8-oxide isoform GSTM4, at pH 7.4 and 25°C Callithrix jacchus
10
-
 styrene 7,8-oxide isoform GSTT4, at pH 7.4 and 25°C Callithrix jacchus
13.3
-
 styrene 7,8-oxide isoform GSTT1, at pH 7.4 and 25°C Callithrix jacchus
21.7
-
 styrene 7,8-oxide isoform GSTM3, at pH 7.4 and 25°C Callithrix jacchus
23.3
-
 1-iodohexane isoform GSTM2, at pH 7.4 and 25°C Callithrix jacchus
23.3
-
 1-iodohexane isoform GSTM3, at pH 7.4 and 25°C Callithrix jacchus
26.7
-
 1-iodohexane isoform GSTM4, at pH 7.4 and 25°C Callithrix jacchus
36.7
-
 styrene 7,8-oxide isoform GSTM2, at pH 7.4 and 25°C Callithrix jacchus
45
-
 styrene 7,8-oxide isoform GSTM5, at pH 7.4 and 25°C Callithrix jacchus
88.3
-
 1-iodohexane isoform GSTM5, at pH 7.4 and 25°C Callithrix jacchus
121.7
-
 1-iodohexane isoform GSTT1, at pH 7.4 and 25°C Callithrix jacchus