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Literature summary for 2.4.99.16 extracted from

  • Lee, W.L.; Hsu, T.W.; Hung, W.C.; Fang, J.M.
    A copper(ii)-dipicolylamine-coumarin sensor for maltosyltransferase assay (2019), Dalton Trans., 48, 8026-8029 .
    View publication on PubMed

Application

Application Comment Organism
drug development a coumarin-based Cu(II)-mDPA sensor (Cu-1b) is developed using internal charge transfer as the sensing mechanism for the selective detection of phosphate ions in HEPES buffer with an association constant of 140000/M. The Cu(II)-di(methylpyridylmethyl)amine-coumarin sensor acts as a robust and sensitive sensor to probe the enzyme-catalyzed reaction. This fluorescence turn-on assay may facilitate the screening of GlgE inhibitors for the discovery of new anti-tuberculosis drugs Mycobacterium tuberculosis

Organism

Organism UniProt Comment Textmining
Mycobacterium tuberculosis P9WQ17
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Mycobacterium tuberculosis ATCC 25618 P9WQ17
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Synonyms

Synonyms Comment Organism
GlgE
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Mycobacterium tuberculosis