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Literature summary for 2.4.3.1 extracted from

  • Nakamura, M.; Tsunoda, A.; Yanagisawa, K.; Furukawa, Y.; Kikuchi, J.; Iwase, S.; Sakai, T.; Larson, G.; Saito, M.
    CMP-NeuAc:Galbeta1->4GlcNAc alpha2->6sialyltransferase catalyzes NeuAc transfer to glycolipids (1997), J. Lipid Res., 38, 1795-1806.
    View publication on PubMed
Search for more literature for 2.4.3.1

Activating Compound

Activating Compound Comment Organism Structure
Triton CF-54/Tween 80
-
 Homo sapiens
Triton CF-54/Tween 80
-
 Rattus norvegicus

Cloned(Commentary)

Cloned (Comment) Organism
DNA sequence determination, functional overexpression of full length cDNA and fragment of residues 113-1227, the latter fused to staphylococcal protein A, in COS-1 cells Homo sapiens

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
additional information
-
 additional information
-
 Homo sapiens
additional information
-
 additional information
-
 Rattus norvegicus
0.05
-
 CMP-N-acetylneuraminate
-
 Homo sapiens
0.05
-
 CMP-N-acetylneuraminate
-
 Rattus norvegicus
0.16
-
 asialo-transferrin recombinant enzyme Homo sapiens
0.2
-
 asialo-alpha1-acid glycoprotein recombinant enzyme Homo sapiens
0.28
-
 asialo-alpha1-acid glycoprotein recombinant enzyme Homo sapiens
0.91
-
 nLc4Cer recombinant enzyme Homo sapiens
1.3
-
 pyridylamino-N-acetyllactosamine recombinant enzyme Homo sapiens
1.5
-
 pyridylamino-nLc4Cer recombinant enzyme Homo sapiens
102
-
 pyridylamino-lactose recombinant enzyme Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-
Rattus norvegicus
-
 commercial product
-

Purification (Commentary)

Purification (Comment) Organism
further purification of commercial rat liver enzyme Rattus norvegicus
recombinant from COS-1 cells Homo sapiens

Source Tissue

Source Tissue Comment Organism Textmining
Burkitt lymphoma cell Daudi cell line Homo sapiens
-
commercial preparation
-
 Rattus norvegicus
-
liver
-
 Homo sapiens
-
liver
-
 Rattus norvegicus
-
myeloma cell line
-
 Homo sapiens
-
U-266 cell myeloma cell line Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
CMP-N-acetylneuraminate + asialo-orosomucoid i.e. asialo-alpha1 acid glycoprotein Homo sapiens CMP + orosomucoid
-
 ?
CMP-N-acetylneuraminate + asialo-orosomucoid i.e. asialo-alpha1 acid glycoprotein Rattus norvegicus CMP + orosomucoid
-
 ?
CMP-N-acetylneuraminate + asialo-transferrin
-
 Homo sapiens CMP + transferrin
-
 ?
CMP-N-acetylneuraminate + asialo-transferrin
-
 Rattus norvegicus CMP + transferrin
-
 ?
CMP-N-acetylneuraminate + beta-D-galactosyl-1,4-N-acetyl-beta-D-glucosaminyl-R acceptor substrate specificity Homo sapiens CMP + alpha-N-acetylneuraminyl-2,6-beta-D-galactosyl-1,4-N-acetyl-beta-D-glucosaminyl-R
-
 ?
CMP-N-acetylneuraminate + beta-D-galactosyl-1,4-N-acetyl-beta-D-glucosaminyl-R acceptor substrate specificity Rattus norvegicus CMP + alpha-N-acetylneuraminyl-2,6-beta-D-galactosyl-1,4-N-acetyl-beta-D-glucosaminyl-R
-
 ?
CMP-N-acetylneuraminate + beta-D-galactosyl-1,4-N-acetyl-beta-D-glucosaminyl-R sialic acid is linked to C-6 of the galactose residue Homo sapiens CMP + alpha-N-acetylneuraminyl-2,6-beta-D-galactosyl-1,4-N-acetyl-beta-D-glucosaminyl-R
-
 ?
CMP-N-acetylneuraminate + beta-D-galactosyl-1,4-N-acetyl-beta-D-glucosaminyl-R sialic acid is linked to C-6 of the galactose residue Rattus norvegicus CMP + alpha-N-acetylneuraminyl-2,6-beta-D-galactosyl-1,4-N-acetyl-beta-D-glucosaminyl-R
-
 ?
CMP-N-acetylneuraminate + pyridylamino-lactose recombinant enzyme Homo sapiens CMP + alpha-N-acetylneuraminyl-2,6-beta-D-galactosyl-1,4-beta-D-glucosyl-pyridylaminoside
-
 ?
CMP-N-acetylneuraminate + pyridylamino-N-acetyllactosamine
-
 Homo sapiens ?
-
 ?
CMP-N-alpha-neuraminate + ganglioside nLc4Cer
-
 Homo sapiens ?
-
 ?
CMP-N-alpha-neuraminate + ganglioside nLc6Cer
-
 Homo sapiens ?
-
 ?
CMP-N-alpha-neuraminate + pyridylaminated ganglioside nLc4Cer
-
 Homo sapiens ?
-
 ?
additional information no activity with Lc4Cer and Lc3Cer Homo sapiens ?
-
 ?