Crystallization (Comment) | Organism |
---|---|
in complex with inhibitors (2R,3R,4S,5R,6R)-3,4,5-trihydroxy-2-hydroxymethyl-7,9-diaza-1-oxa-spiro[4,5]decane-8,10-dione, (2R,3R,4S,5R,6R)-3,4,5,9-tetrahydroxy-2-hydroxymethyl-7,9-diaza-1-oxa-spiro[4,5]decane-8,10-dione, 1-deoxy-1-methoxycarbonylamino-beta-D-glucopyranose. Inhibitors bind at the active site of the enzyme and induce minor movements of the side chains of D283 and N284 that block access of the substrate glycogen to the catalytic site | Oryctolagus cuniculus |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
(2R,3R,4S,5R,6R)-3,4,5,9-tetrahydroxy-2-hydroxymethyl-7,9-diaza-1-oxa-spiro[4,5]decane-8,10-dione | - |
Oryctolagus cuniculus | |
(2R,3R,4S,5R,6R)-3,4,5-trihydroxy-2-hydroxymethyl-7,9-diaza-1-oxa-spiro[4,5]decane-8,10-dione | - |
Oryctolagus cuniculus | |
1-deoxy-1-methoxycarbonylamino-beta-D-glucopyranose | - |
Oryctolagus cuniculus |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Oryctolagus cuniculus | P00489 | - |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
muscle | - |
Oryctolagus cuniculus | - |
Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
---|---|---|---|---|---|
0.0031 | - |
(2R,3R,4S,5R,6R)-3,4,5-trihydroxy-2-hydroxymethyl-7,9-diaza-1-oxa-spiro[4,5]decane-8,10-dione | pH 6.8, 30°C | Oryctolagus cuniculus | |
0.0393 | - |
(2R,3R,4S,5R,6R)-3,4,5,9-tetrahydroxy-2-hydroxymethyl-7,9-diaza-1-oxa-spiro[4,5]decane-8,10-dione | - |
Oryctolagus cuniculus | |
0.086 | - |
1-deoxy-1-methoxycarbonylamino-beta-D-glucopyranose | - |
Oryctolagus cuniculus |