Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
[E1 NEDD8-activating enzyme]-S-[NEDD8 protein]-yl-L-cysteine + [E2 NEDD8-conjugating enzyme]-L-cysteine | Homo sapiens | - |
[E1 NEDD8-activating enzyme]-L-cysteine + [E2 NEDD8-conjugating enzyme]-S-[NEDD8-protein]-yl-L-cysteine | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
A-427 cell | - |
Homo sapiens | - |
lung cancer cell | - |
Homo sapiens | - |
NCI-H1299 cell | - |
Homo sapiens | - |
NCI-H2170 cell | - |
Homo sapiens | - |
NCI-H358 cell | - |
Homo sapiens | - |
SK-MES-1 cell | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
[E1 NEDD8-activating enzyme]-S-[NEDD8 protein]-yl-L-cysteine + [E2 NEDD8-conjugating enzyme]-L-cysteine | - |
Homo sapiens | [E1 NEDD8-activating enzyme]-L-cysteine + [E2 NEDD8-conjugating enzyme]-S-[NEDD8-protein]-yl-L-cysteine | - |
? |
Synonyms | Comment | Organism |
---|---|---|
neddylation conjugating E2 enzyme | - |
Homo sapiens |
Ubc12 | - |
Homo sapiens |
UBE2F | - |
Homo sapiens |
UBE2M | - |
Homo sapiens |
Organism | Comment | Expression |
---|---|---|
Homo sapiens | UBE2M is a stress-inducible gene subjected to cis-trans-activation by hypoxia-inducible factor-1alpha and transcription factor AP-1. MLN4924, a small molecule inhibitor of E1 NEDD8-activating enzyme, up-regulates UBE2M via blocking degradation of hypoxia-inducible factor-1alpha and transcription factor AP-1 | up |
General Information | Comment | Organism |
---|---|---|
physiological function | UBE2M is a dual E2 for targeted ubiquitylation and degradation of UBE2F, acting as a neddylation E2 to activate cullin 3-Keap1 E3 under physiological condition, but as an ubiquitylation E2 for Parkin-DJ-1 E3 under stressed conditions. UBE2M-induced UBE2F degradation leads to CRL5 inactivation and subsequent NOXA accumulation to suppress the growth of lung cancer cells | Homo sapiens |