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Literature summary for 2.3.2.27 extracted from
- The RING finger E3 ligases PIR1 and PIR2 mediate PP2CA degradation to enhance abscisic acid response in Arabidopsis (2019), Plant J., 100, 473-486 .
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Arabidopsis thaliana | - |
- |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| leaf | presence of splicing isoform Pir1.2 | Arabidopsis thaliana | - |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| PIR1 | - |
Arabidopsis thaliana |
| PIR2 | - |
Arabidopsis thaliana |
| PP2CA interacting RING finger protein 1 | - |
Arabidopsis thaliana |
| PP2CA interacting RING finger protein 2 | - |
Arabidopsis thaliana |
General Information
| General Information | Comment | Organism |
|---|---|---|
| physiological function | RING E3 ligase PIR2 interacts with protein phosphatase PP2CA. A PIR2 knockout mutant does not display altered response to abscisic acid, the PIR1-1/PIR2 double mutant becomes more insensitive to abscisic acid than the wild-type or PIR1-1 and PIR2 single mutants | Arabidopsis thaliana |
| physiological function | splicing isoform PIR1.2 exhibits E3 ligase activity and determines protein phosphatase PP2CA's stability in the presence of abscisic acid. The PIR1 knockout mutant displays an abscisic acid-hyposensitive phenotype. A PIR1-1/PIR2 double mutant becomes more insensitive to abscisic acid than the wild-type or PIR1-1 and PIR2 single mutants | Arabidopsis thaliana |
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