Cloned (Comment) | Organism |
---|---|
expressed in INS-1E cells | Mus musculus |
Protein Variants | Comment | Organism |
---|---|---|
C277A | the mutant lacks transamidation function | Mus musculus |
I331N | the mutant is associated with early-onset type 2 diabetes, has no GTP-binding ability and shows 32% of wild type activity | Mus musculus |
M330R | the mutant is associated with early-onset type 2 diabetes, has very weak GTP-binding ability and shows 20% of wild type activity | Mus musculus |
N333S | the mutant is associated with early-onset type 2 diabetes, has elevated GTP-binding ability and shows 7% of wild type activity | Mus musculus |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Ca2+ | dependent on | Mus musculus |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Mus musculus | - |
- |
- |
Synonyms | Comment | Organism |
---|---|---|
TG2 | - |
Mus musculus |
transglutaminase 2 | - |
Mus musculus |
General Information | Comment | Organism |
---|---|---|
malfunction | transglutaminase 2 (TG2) mutations are associated with diabetes type 2. Lack of TG2 reduces glucose-stimulated insulin secretion from the pancreatic islets | Mus musculus |