C277S |
mutation of active site. Mutant still binds 6 Ca2+ |
Homo sapiens |
D151N/E153Q/E154Q/E155Q/E158Q |
mutation of calcium binding site, does not cause major structural alterations. Mutant binds less than 6 Ca2+ and is deficient in transglutaminase activity. GTPase activity is activated by presence of Ca2+ |
Homo sapiens |
D306N/N308S/N310S |
mutation of calcium binding site, does not cause major structural alterations. Mutant binds less than 6 Ca2+ and is deficient in transglutaminase activity |
Homo sapiens |
D434N/E435Q/E437N |
mutation of calcium binding site, does not cause major structural alterations. Mutant binds less than 6 Ca2+ and is deficient in transglutaminase activity. GTPase activity is activated by presence of Ca2+ |
Homo sapiens |
E396Q/N398S/D400N |
mutation of calcium binding site, does not cause major structural alterations. Mutant binds less than 6 Ca2+ and is deficient in transglutaminase activity |
Homo sapiens |
E447Q/E451Q/E452Q/E454Q |
mutation of calcium binding site, does not cause major structural alterations. Mutant binds less than 6 Ca2+ and is deficient in transglutaminase activity |
Homo sapiens |
N229S/N231S/D232N/D233N |
mutation of calcium binding site, does not cause major structural alterations. Mutant binds less than 6 Ca2+ and is deficient in transglutaminase activity |
Homo sapiens |