Application | Comment | Organism |
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medicine | central role of TG2 in the mechanistic pathway of CF inflammation, opening a possible new wave of therapies for sufferers of chronic inflammatory diseases | Homo sapiens |
Organism | UniProt | Comment | Textmining |
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Homo sapiens | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
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bronchial epithelial cell | ex vivo cultures of nasal polyp mucosal explants of Cystic fibrosis patients and controls, cystic fibrosis transmembrane conductance regulator-defective IB3-1 bronchial epithelial cells, C38 isogenic CFTR corrected, and 16HBE normal bronchial epithelial cell lines. A defective cystic fibrosis transmembrane conductance regulator induces a remarkable up-regulation of tissue transglutaminase in both tissues and cell lines. The increased TG2 activity leads to functional sequestration of the anti-inflammatory peroxisome proliferator-activated receptor gamma and increase of the classic parameters of inflammation | Homo sapiens | - |