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Literature summary for 2.3.1.B41 extracted from

  • Hu, J.; Deng, F.; Hu, X.; Zhang, W.; Zeng, X.; Tian, X.
    Histone deacetylase SIRT6 regulates chemosensitivity in liver cancer cells via modulation of FOXO3 activity (2018), Oncol. Rep., 40, 3635-3644 .
    View publication on PubMedView publication on EuropePMC
Search for more literature for 2.3.1.B41

Cloned(Commentary)

Cloned (Comment) Organism
gene SIRT6, transient overexpression of FLAG-tagged SIRT6 in HeLa cells, quantitative reverse transcription PCR enzyme expression analysis Homo sapiens

Protein Variants

Protein Variants Comment Organism
additional information specific downregulation of histone deacetylase sirtuin 6 (SIRT6), overexpression of SIRT6. In Hep-G2 cells, doxorubicin treatment results in significant increases in SIRT1 and SIRT4 mRNA expression and downregulation of SIRT6 mRNA level by 36 h Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
NAD+ + [protein]-N6-palmitoyl-L-lysine Homo sapiens
-
 nicotinamide + [protein]-L-lysine + 2'-O-palmitoyl-ADP ribose
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens Q8N6T7
-
-

Source Tissue

Source Tissue Comment Organism Textmining
Hep-G2 cell
-
 Homo sapiens
-
hepatoma cell
-
 Homo sapiens
-
Huh-7 cell
-
 Homo sapiens
-
liver
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
NAD+ + [protein]-N6-palmitoyl-L-lysine
-
 Homo sapiens nicotinamide + [protein]-L-lysine + 2'-O-palmitoyl-ADP ribose
-
 ?

Synonyms

Synonyms Comment Organism
histone deacetylase
-
 Homo sapiens
SIRT6
-
 Homo sapiens
sirtuin 6
-
 Homo sapiens

Cofactor

Cofactor Comment Organism Structure
NAD+
-
 Homo sapiens

Expression

Organism Comment Expression
Homo sapiens in Hep-G2 cells, doxorubicin treatment results in significant increases in SIRT1 and SIRT4 mRNA expression and downregulation of SIRT6 mRNA level by 36 h down

General Information

General Information Comment Organism
malfunction downregulation of SIRT6 enables forkhead box O3 (FOXO3) upregulation, translocation into the nucleus, and increased expression of its target genes p27 and Bim, which further induce apoptosis. Overexpression of SIRT6, but not enzyme-inactivated mutants, prevents FOXO3 translocation into the nucleus and doxorubicin-induced cell death Homo sapiens
physiological function histone deacetylase SIRT6, one of the SIRT proteins, plays critical roles in controlling metabolism, genomic stability, inflammation, aging and cancer progression. SIRT6 regulates chemosensitivity in liver cancer cells via modulation of FOXO3 activity. SIRT6 interacts with FOXO3 and this interaction increases FOXO3 ubiquitination and decreases its stability. The effect of SIRT6 in preventing doxorubicin-induced cell death requires FOXO3. Overexpression of SIRT6 could not prevent doxorubicin-induced cell death in FOXO3 knockdown cells. SIRT6 plays a central role in determining doxorubicin-induced cell death via modulation of FOXO3 activity Homo sapiens