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Literature summary for 2.3.1.B41 extracted from

  • Etchegaray, J.P.; Chavez, L.; Huang, Y.; Ross, K.N.; Choi, J.; Martinez-Pastor, B.; Walsh, R.M.; Sommer, C.A.; Lienhard, M.; Gladden, A.; Kugel, S.; Silberman, D.M.; Ramaswamy, S.; Mostoslavsky, G.; Hochedlinger, K.; Goren, A.; Rao, A.; Mostoslavsky, R.
    The histone deacetylase SIRT6 controls embryonic stem cell fate via TET-mediated production of 5-hydroxymethylcytosine (2015), Nat. Cell Biol., 17, 545-557.
    View publication on PubMedView publication on EuropePMC
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Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
NAD+ + [histone H3]-N6-acetyl-L-lysine56 Mus musculus
-
 nicotinamide + [histone H3]-L-lysine + 2'-O-acetyl-ADP ribose
-
 ?
NAD+ + [histone H3]-N6-acetyl-L-lysine9 Mus musculus
-
 nicotinamide + [histone H3]-L-lysine + 2'-O-acetyl-ADP ribose
-
 ?

Organism

Organism UniProt Comment Textmining
Mus musculus P59941
-
-

Source Tissue

Source Tissue Comment Organism Textmining
embryonic stem cell
-
 Mus musculus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
NAD+ + [histone H3]-N6-acetyl-L-lysine56
-
 Mus musculus nicotinamide + [histone H3]-L-lysine + 2'-O-acetyl-ADP ribose
-
 ?
NAD+ + [histone H3]-N6-acetyl-L-lysine9
-
 Mus musculus nicotinamide + [histone H3]-L-lysine + 2'-O-acetyl-ADP ribose
-
 ?

Synonyms

Synonyms Comment Organism
SIRT6
-
 Mus musculus
sirtuin 6
-
 Mus musculus

Cofactor

Cofactor Comment Organism Structure
NAD+ dependent on Mus musculus

General Information

General Information Comment Organism
malfunction enzyme knockout is associated with derepression of Oct4, Sox2 and Nanog, which in turn causes an upregulation of Tet enzymes and elevated production of 5-hydroxymethylcytosine Mus musculus
physiological function the enzyme controls embryonic stem cell fate via TET-mediated production of 5-hydroxymethylcytosine Mus musculus