Crystallization (Comment) | Organism |
---|---|
structure of Erg10A and its complex with CoA, four substitutions within the CoA binding site are different from human orthologues | Aspergillus fumigatus |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.026 | - |
CoA | pH 8.1, 30°C | Aspergillus fumigatus | |
0.043 | - |
acetoacetyl-CoA | pH 8.1, 30°C | Aspergillus fumigatus | |
0.232 | - |
acetyl-CoA | pH 8.1, 30°C | Aspergillus fumigatus |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
mitochondrion | - |
Aspergillus fumigatus | 5739 | - |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Aspergillus fumigatus | B0XMC1 | - |
- |
Aspergillus fumigatus CEA10 | B0XMC1 | - |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
2 acetyl-CoA | - |
Aspergillus fumigatus | CoA + acetoacetyl-CoA | - |
r | |
2 acetyl-CoA | - |
Aspergillus fumigatus CEA10 | CoA + acetoacetyl-CoA | - |
r | |
CoA + acetoacetyl-CoA | - |
Aspergillus fumigatus | 2 acetyl-CoA | - |
r | |
CoA + acetoacetyl-CoA | - |
Aspergillus fumigatus CEA10 | 2 acetyl-CoA | - |
r | |
additional information | Erg10A is a functional acetyl-CoA acetyltransferase catalyzing both synthetic and degradative reactions | Aspergillus fumigatus | ? | - |
- |
|
additional information | Erg10A is a functional acetyl-CoA acetyltransferase catalyzing both synthetic and degradative reactions | Aspergillus fumigatus CEA10 | ? | - |
- |
Synonyms | Comment | Organism |
---|---|---|
AFUB_000550 | - |
Aspergillus fumigatus |
Erg10A | - |
Aspergillus fumigatus |
Turnover Number Minimum [1/s] | Turnover Number Maximum [1/s] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
3 | - |
acetoacetyl-CoA | pH 8.1, 30°C | Aspergillus fumigatus | |
5 | - |
CoA | pH 8.1, 30°C | Aspergillus fumigatus | |
7 | - |
acetyl-CoA | pH 8.1, 30°C | Aspergillus fumigatus |
General Information | Comment | Organism |
---|---|---|
physiological function | Erg10A is essential for the survival of Neosartoya fumigata. The reduced expression of Erg10A leads to severe morphological defects and increased susceptibility to oxidative and cell wall stresses | Aspergillus fumigatus |