Literature summary for 2.3.1.87 extracted from

Wadas, B.; Borjigin, J.; Huang, Z.; Oh, J.H.; Hwang, C.S.; Varshavsky, A.
Degradation of serotonin N-acetyltransferase, a circadian regulator, by the N-end rule pathway (2016), J. Biol. Chem., 291, 17178-17196 .

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Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	Q16613	-	-
Rattus norvegicus	Q64666	-	-

General Information

General Information	Comment	Organism
metabolism	N-terminally acetylated Ac-AANAT is degraded through the recognition of its N-terminally acetylated N-terminal Met residue by the Ac/N-end rule pathway, whereas the non-N-terminally acetylated AANAT is targeted by the Arg/N-end rule pathway, which recognizes the unacetylated N-terminal Met-Leu sequence of rat AANAT. Degradation of Lys8Arg mutants of rat AANAT is mediated by polyubiquitylation of its Lys residue(s)	Rattus norvegicus
metabolism	the N-terminal sequence of human AANAT differs from that of rodent AANATs. The human enzyme is longer-lived than its rat counterpart and appears to be refractory to degradation by the N-end rule pathway	Homo sapiens

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Release 2023.1 (January 2023)