Literature summary for 2.3.1.78 extracted from

Choi, Y.; Tuzikov, A.; Ovchinnikova, T.; Bovin, N.; Pshezhetsky, A.
Novel direct assay for acetyl-CoA alpha-glucosaminide N-acetyltransferase using BODIPY-glucosamine as a substrate (2016), JIMD Rep., 28, 11-18 .

Search for more literature for 2.3.1.78

Application

Application	Comment	Organism
analysis	direct method to assay HGSNAT enzymatic activity using fluorescent BODIPY-glucosamine as a substrate. The assay is specific and potentially applicable for the biochemical diagnosis of mucopolysaccharidosis III type and high-throughput screening for HGSNAT inhibitors	Homo sapiens

Cloned(Commentary)

Cloned (Comment)	Organism
expression in COS-7 cell	Homo sapiens

Inhibitors

Inhibitors	Comment	Organism	Structure
D-glucosamine	-	Homo sapiens

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	Q68CP4	-	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
acetyl-CoA + BODIPY-beta-D-glucosaminide	-	Homo sapiens	CoA + BODIPY-N-acetyl-beta-D-glucosaminide	-	?

pH Optimum

pH Optimum Minimum	pH Optimum Maximum	Comment	Organism
6.5	-	-	Homo sapiens

Ki Value [mM]

Ki Value [mM]	Ki Value maximum [mM]	Inhibitor	Comment	Organism	Structure
0.26	-	D-glucosamine	pH 6.5, 37°C	Homo sapiens

Use of this online version of BRENDA is free under the CC BY 4.0 license. See terms of use for full details.

Release 2023.1 (January 2023)