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Literature summary for 2.3.1.262 extracted from
- Recent advances in the discovery of PqsD inhibitors as antimicrobial agents (2017), ChemMedChem, 12, 420-425 .
Application
| Application | Comment | Organism |
|---|---|---|
| drug development | antivirulence concepts through the inhibition of PqsD in the treatment of bacterial infections | Pseudomonas aeruginosa |
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| (2-nitrophenyl)(phenyl)methanol | - |
Pseudomonas aeruginosa |  |
| (2E)-3-(thiophen-3-yl)prop-2-enoic acid | - |
Pseudomonas aeruginosa | |
| (2R)-2,4-dihydroxy-N-(3-[[4-hydroxy-4-(2-nitrophenyl)butyl]amino]-3-oxopropyl)-3,3-dimethylbutanamide | - |
Pseudomonas aeruginosa | |
| (E)-1-(2-chloro-8-methylquinolin-3-yl)-N-[3-fluoro-4-(morpholin-4-yl)phenyl]methanimine | - |
Pseudomonas aeruginosa | |
| (E)-1-(2-chloroquinolin-3-yl)-N-[3-fluoro-4-(morpholin-4-yl)phenyl]methanimine | - |
Pseudomonas aeruginosa | |
| 1-(2-nitrophenyl)propan-1-ol | - |
Pseudomonas aeruginosa | |
| 1-methyl-2-methylideneimidazolidine | - |
Pseudomonas aeruginosa | |
| 2-(3,4-dichlorobenzene-1-sulfonyl)-4-(1H-tetrazol-1-yl)pyrimidine | - |
Pseudomonas aeruginosa | |
| 2-(benzenesulfonyl)-4-(1H-tetrazol-1-yl)pyrimidine | - |
Pseudomonas aeruginosa | |
| 2-(hexane-1-sulfonyl)-4-(1H-1,2,3-triazol-1-yl)pyrimidine | - |
Pseudomonas aeruginosa | |
| 2-(methanesulfonyl)-4-(1H-1,2,3-triazol-1-yl)pyrimidine | - |
Pseudomonas aeruginosa | |
| 2-(methanesulfonyl)-4-(1H-tetrazol-1-yl)pyrimidine | - |
Pseudomonas aeruginosa | |
| 2-(methanesulfonyl)-4-(4-phenyl-1H-1,2,3-triazol-1-yl)pyrimidine | - |
Pseudomonas aeruginosa | |
| 2-(methanesulfonyl)-4-phenoxy-6-(1H-1,2,3-triazol-1-yl)pyrimidine | - |
Pseudomonas aeruginosa | |
| 2-[([1,1'-biphenyl]-4-carbonyl)amino]-3-chlorobenzoic acid | - |
Pseudomonas aeruginosa | |
| 2-[([1,1'-biphenyl]-4-carbonyl)amino]benzoic acid | - |
Pseudomonas aeruginosa | |
| 2-[3-(diethylsulfamoyl)benzamido]-6-hydroxybenzoic acid | - |
Pseudomonas aeruginosa | |
| 2-[3-hydroxy-3-(2-nitrophenyl)propyl]-1H-isoindole-1,3(2H)-dione | - |
Pseudomonas aeruginosa | |
| 3-(3,4-dihydroxyphenyl)propanoic acid | - |
Pseudomonas aeruginosa | |
| 3-(3-carboxypropanamido)-5-(4-methoxyphenyl)thiophene-2-carboxylic acid | - |
Pseudomonas aeruginosa | |
| 3-([[(1S)-1-carboxy-2-phenylethyl]carbamoyl]amino)-7-methoxy-4,5-dihydronaphtho[1,2-b]thiophene-2-carboxylic acid | - |
Pseudomonas aeruginosa | |
| 3-([[(1S)-1-carboxy-3-phenylpropyl]carbamoyl]amino)-5-(4-methoxyphenyl)thiophene-2-carboxylic acid | - |
Pseudomonas aeruginosa | |
| 3-([[(S)-carboxy(phenyl)methyl]carbamoyl]amino)-5-(4-methoxyphenyl)thiophene-2-carboxylic acid | - |
Pseudomonas aeruginosa | |
| 3-[[benzyl(ethyl)carbamoyl]amino]-5-(4-methoxyphenyl)thiophene-2-carboxylic acid | - |
Pseudomonas aeruginosa | |
| 4-[3-(diethylsulfamoyl)benzamido][1,1'-biphenyl]-3-carboxylic acid | - |
Pseudomonas aeruginosa | |
| benzyl 3-(3,4-dihydroxyphenyl)propanoate | - |
Pseudomonas aeruginosa | |
| methyl (2E)-3-(3,4-dihydroxyphenyl)prop-2-enoate | - |
Pseudomonas aeruginosa | |
| methyl 4-(3,4-dihydroxyphenyl)butanoate | - |
Pseudomonas aeruginosa | |
| N-([(5R)-3-[3-fluoro-4-(morpholin-4-yl)phenyl]-2-oxo-1,3-oxazolidin-5-yl]methyl)acetamide | - |
Pseudomonas aeruginosa | |
| N-([2-carboxy-5-[4'-(hydroxymethyl)[1,1'-biphenyl]-4-yl]thiophen-3-yl]carbamoyl)-L-phenylalanine | - |
Pseudomonas aeruginosa | |
| N-([2-carboxy-5-[4-(2-chloroacetamido)phenyl]thiophen-3-yl]carbamoyl)-L-phenylalanine | - |
Pseudomonas aeruginosa | |
| N-[(2-carboxy-5-phenylthiophen-3-yl)carbamoyl]-L-phenylalanine | - |
Pseudomonas aeruginosa | |
| N-[(2-carboxy-5-[4'-[hydroxy(2-nitrophenyl)methyl][1,1'-biphenyl]-4-yl]thiophen-3-yl)carbamoyl]-L-phenylalanine | - |
Pseudomonas aeruginosa | |
| N-[[2-carboxy-5-(4-hydroxyphenyl)thiophen-3-yl]carbamoyl]-L-phenylalanine | - |
Pseudomonas aeruginosa | |
| N-[[2-carboxy-5-(4-methoxy-2-methylphenyl)thiophen-3-yl]carbamoyl]-L-phenylalanine | - |
Pseudomonas aeruginosa | |
| N-[[2-carboxy-5-(4-methoxyphenyl)thiophen-3-yl]carbamoyl]-4-chloro-L-phenylalanine | - |
Pseudomonas aeruginosa | |
| N-[[2-carboxy-5-(4-methoxyphenyl)thiophen-3-yl]carbamoyl]-L-phenylalanine | - |
Pseudomonas aeruginosa | |
| N-[[2-carboxy-5-(4-methoxyphenyl)thiophen-3-yl]carbamoyl]-L-tyrosine | - |
Pseudomonas aeruginosa | |
| N-[[3-(furan-2-yl)-1H-pyrazol-5-yl]methyl]-2-(4-methylpiperazin-1-yl)pyrimidin-4-amine | - |
Pseudomonas aeruginosa | |
| propan-2-yl 3-(3,4-dihydroxyphenyl)propanoate | - |
Pseudomonas aeruginosa | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Pseudomonas aeruginosa | P20582 | - |
- |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| PqsD | - |
Pseudomonas aeruginosa |
IC50 Value
| IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
|---|---|---|---|---|---|
| 0.0003 | - |
pH and temperature not specified in the publication | Pseudomonas aeruginosa | 2-[3-hydroxy-3-(2-nitrophenyl)propyl]-1H-isoindole-1,3(2H)-dione | |
| 0.0003 | - |
pH and temperature not specified in the publication | Pseudomonas aeruginosa | 4-[3-(diethylsulfamoyl)benzamido][1,1'-biphenyl]-3-carboxylic acid | |
| 0.00036 | - |
pH and temperature not specified in the publication | Pseudomonas aeruginosa | N-([2-carboxy-5-[4'-(hydroxymethyl)[1,1'-biphenyl]-4-yl]thiophen-3-yl]carbamoyl)-L-phenylalanine | |
| 0.0004 | - |
pH and temperature not specified in the publication | Pseudomonas aeruginosa | 2-(3,4-dichlorobenzene-1-sulfonyl)-4-(1H-tetrazol-1-yl)pyrimidine | |
| 0.0005 | - |
pH and temperature not specified in the publication | Pseudomonas aeruginosa | N-[[2-carboxy-5-(4-methoxyphenyl)thiophen-3-yl]carbamoyl]-L-phenylalanine | |
| 0.0011 | - |
pH and temperature not specified in the publication | Pseudomonas aeruginosa | 1-(2-nitrophenyl)propan-1-ol | |
| 0.0012 | - |
pH and temperature not specified in the publication | Pseudomonas aeruginosa | 2-[3-(diethylsulfamoyl)benzamido]-6-hydroxybenzoic acid | |
| 0.0013 | - |
pH and temperature not specified in the publication | Pseudomonas aeruginosa | 2-[([1,1'-biphenyl]-4-carbonyl)amino]benzoic acid | |
| 0.0014 | - |
pH and temperature not specified in the publication | Pseudomonas aeruginosa | N-[(2-carboxy-5-[4'-[hydroxy(2-nitrophenyl)methyl][1,1'-biphenyl]-4-yl]thiophen-3-yl)carbamoyl]-L-phenylalanine | |
| 0.0017 | - |
pH and temperature not specified in the publication | Pseudomonas aeruginosa | 2-(benzenesulfonyl)-4-(1H-tetrazol-1-yl)pyrimidine | |
| 0.0017 | - |
pH and temperature not specified in the publication | Pseudomonas aeruginosa | 2-(hexane-1-sulfonyl)-4-(1H-1,2,3-triazol-1-yl)pyrimidine | |
| 0.002 | - |
pH and temperature not specified in the publication | Pseudomonas aeruginosa | N-([2-carboxy-5-[4-(2-chloroacetamido)phenyl]thiophen-3-yl]carbamoyl)-L-phenylalanine | |
| 0.0032 | - |
pH and temperature not specified in the publication | Pseudomonas aeruginosa | (2-nitrophenyl)(phenyl)methanol | |
| 0.0032 | - |
pH and temperature not specified in the publication | Pseudomonas aeruginosa | 2-(methanesulfonyl)-4-phenoxy-6-(1H-1,2,3-triazol-1-yl)pyrimidine | |
| 0.0038 | - |
pH and temperature not specified in the publication | Pseudomonas aeruginosa | N-[(2-carboxy-5-phenylthiophen-3-yl)carbamoyl]-L-phenylalanine | |
| 0.0059 | - |
pH and temperature not specified in the publication | Pseudomonas aeruginosa | benzyl 3-(3,4-dihydroxyphenyl)propanoate | |
| 0.006 | - |
pH and temperature not specified in the publication | Pseudomonas aeruginosa | 3-[[benzyl(ethyl)carbamoyl]amino]-5-(4-methoxyphenyl)thiophene-2-carboxylic acid | |
| 0.0062 | - |
pH and temperature not specified in the publication | Pseudomonas aeruginosa | 2-[([1,1'-biphenyl]-4-carbonyl)amino]-3-chlorobenzoic acid | |
| 0.007 | - |
pH and temperature not specified in the publication | Pseudomonas aeruginosa | 3-(3-carboxypropanamido)-5-(4-methoxyphenyl)thiophene-2-carboxylic acid | |
| 0.0075 | - |
pH and temperature not specified in the publication | Pseudomonas aeruginosa | N-[[2-carboxy-5-(4-methoxy-2-methylphenyl)thiophen-3-yl]carbamoyl]-L-phenylalanine | |
| 0.0079 | - |
pH and temperature not specified in the publication | Pseudomonas aeruginosa | (2R)-2,4-dihydroxy-N-(3-[[4-hydroxy-4-(2-nitrophenyl)butyl]amino]-3-oxopropyl)-3,3-dimethylbutanamide | |
| 0.0079 | - |
pH and temperature not specified in the publication | Pseudomonas aeruginosa | methyl 4-(3,4-dihydroxyphenyl)butanoate | |
| 0.0086 | - |
pH and temperature not specified in the publication | Pseudomonas aeruginosa | propan-2-yl 3-(3,4-dihydroxyphenyl)propanoate | |
| 0.0129 | - |
pH and temperature not specified in the publication | Pseudomonas aeruginosa | (E)-1-(2-chloroquinolin-3-yl)-N-[3-fluoro-4-(morpholin-4-yl)phenyl]methanimine | |
| 0.0138 | - |
pH and temperature not specified in the publication | Pseudomonas aeruginosa | N-[[2-carboxy-5-(4-methoxyphenyl)thiophen-3-yl]carbamoyl]-4-chloro-L-phenylalanine | |
| 0.0156 | - |
pH and temperature not specified in the publication | Pseudomonas aeruginosa | (E)-1-(2-chloro-8-methylquinolin-3-yl)-N-[3-fluoro-4-(morpholin-4-yl)phenyl]methanimine | |
| 0.0159 | - |
pH and temperature not specified in the publication | Pseudomonas aeruginosa | N-([(5R)-3-[3-fluoro-4-(morpholin-4-yl)phenyl]-2-oxo-1,3-oxazolidin-5-yl]methyl)acetamide | |
| 0.0216 | - |
pH and temperature not specified in the publication | Pseudomonas aeruginosa | N-[[2-carboxy-5-(4-hydroxyphenyl)thiophen-3-yl]carbamoyl]-L-phenylalanine | |
| 0.0237 | - |
pH and temperature not specified in the publication | Pseudomonas aeruginosa | 3-([[(1S)-1-carboxy-2-phenylethyl]carbamoyl]amino)-7-methoxy-4,5-dihydronaphtho[1,2-b]thiophene-2-carboxylic acid | |
| 0.027 | - |
pH and temperature not specified in the publication | Pseudomonas aeruginosa | 3-(3,4-dihydroxyphenyl)propanoic acid | |
| 0.029 | - |
pH and temperature not specified in the publication | Pseudomonas aeruginosa | N-[[2-carboxy-5-(4-methoxyphenyl)thiophen-3-yl]carbamoyl]-L-tyrosine | |
| 0.051 | - |
pH and temperature not specified in the publication | Pseudomonas aeruginosa | methyl (2E)-3-(3,4-dihydroxyphenyl)prop-2-enoate | |
General Information
| General Information | Comment | Organism |
|---|---|---|
| metabolism | PqsD is an enzyme essential for the Pseudomonas aeruginosa quorum-sensing apparatus, which catalyzes the final and key step in the biosynthesis of 4-hydroxy-2-heptylquinolone, which is a signal molecule of the Pseudomonas aeruginosa quorum-sensing system | Pseudomonas aeruginosa |
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