Application | Comment | Organism |
---|---|---|
drug development | LpxL2 might be a candidate target in the development of anti-Klebsiella pneumoniae drugs | Klebsiella pneumoniae |
Cloned (Comment) | Organism |
---|---|
expression in Escherichia coli | Klebsiella pneumoniae |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Klebsiella pneumoniae | W9B4X1 | - |
- |
Klebsiella pneumoniae | W9BFU2 | - |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
a dodecanoyl-[acyl-carrier protein] + Kdo2-lipid IVA | - |
Klebsiella pneumoniae | dodecanoyl-Kdo2-lipid IVA + an [acyl-carrier protein] | - |
? | |
a tetradecanoyl-[acyl-carrier protein] + Kdo2-lipid IVA | - |
Klebsiella pneumoniae | tetradecanoyl-Kdo2-lipid IVA + an [acyl-carrier protein] | - |
? |
Synonyms | Comment | Organism |
---|---|---|
LpxL1 | - |
Klebsiella pneumoniae |
LpxL2 | - |
Klebsiella pneumoniae |
Organism | Comment | Expression |
---|---|---|
Klebsiella pneumoniae | the enzyme (LpxL1) is negatively regulated by the two-component system PhoPQ | down |
General Information | Comment | Organism |
---|---|---|
malfunction | lipid A produced by the lpxL2 mutant lacks the 2-hydroxymyristate, palmitate, and 4-aminoarabinose decorations found in the lipid A synthesized by the wild type. The lack of 2-hydroxymyristate is expected since LpxO modifies the myristate transferred by LpxL2 to the lipid A. The absence of the other two decorations is most likely caused by the downregulation of phoPQ and pmrAB expression | Klebsiella pneumoniae |
physiological function | LpxL2-dependent lipid A acylation protects Klebsiella from polymyxins, mediates resistance to phagocytosis, limits the activation of inflammatory responses by macrophages, and is required for pathogen survival in the wax moth (Galleria mellonella). LpxL2 contribution to virulence is dependent on LpxO-mediated hydroxylation of the LpxL2-transferred myristate | Klebsiella pneumoniae |