Literature summary for 2.3.1.21 extracted from

Calderon-Dominguez, M.; Sebastian, D.; Fucho, R.; Weber, M.; Mir, J.F.; Garcia-Casarrubios, E.; Obregon, M.J.; Zorzano, A.; Valverde, A.M.; Serra, D.; Herrero, L.
Carnitine palmitoyltransferase 1 increases lipolysis, UCP1 protein expression and mitochondrial activity in brown adipocytes (2016), PLoS ONE, 11, e0159399 .

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Cloned(Commentary)

Cloned (Comment)	Organism
expression in rat brown adipocyte cell line	Homo sapiens

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	P50416	-	-

General Information

General Information	Comment	Organism
physiological function	heterologous expression of a constitutively active CPT1A variant in brown adipocyte cells leads to increased fatty acid oxidation, lipolysis, UCP1 protein levels and mitochondrial activity. Enhanced fatty acid oxidation reduces the palmitate-induced increase in triglyceride content and the expression of obese and inflammatory markers	Homo sapiens

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Release 2023.1 (January 2023)