Literature summary for 2.3.1.21 extracted from

Guan, L.; Chen, Y.; Wang, Y.; Zhang, H.; Fan, S.; Gao, Y.; Jiao, T.; Fu, K.; Sun, J.; Yu, A.; Huang, M.; Bi, H.
Effects of carnitine palmitoyltransferases on cancer cellular senescence (2019), J. Cell. Physiol., 234, 1707-1719 .

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Application

Application	Comment	Organism
medicine	compared to isoforms CPT1A, CPT1B and CPT2, isoform CPT1C exerts the most significant effect on mitochondrial dysfunction-associated tumor cellular senescence among the members of the CPT family	Homo sapiens

Localization

Localization	Comment	Organism	GeneOntology No.	Textmining
mitochondrion	-	Homo sapiens	5739	-

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	P23786	mitochondrial isoform isoform CTP1B	-
Homo sapiens	Q8TCG5	brain isoform CTP1C	-
Homo sapiens	Q92523	muscle isoform isoform CTP1B	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
MDA-MB-231 cell	-	Homo sapiens	-
PANC-1 cell	-	Homo sapiens	-

General Information

General Information	Comment	Organism
physiological function	silencing of CPT1C by siRNA leads to a significant decrease in DNA synthesis and weaker colony-forming capacities in PANC-1 and MDA-MB-231 cells. CPT1C-depleted PANC-1 and MDA-MB-231 cells arrest the cell cycle in G1 phase, changing this cell population from 30.0% to 58.0% and 50.3% to 56.0%, respectively. Silencing increases intracellular lipid content by 1.45fold. CPT1C knockdown cells accumulate intracellular ROS, compared with the negative control, by 2.8fold and causes rapid RH123 dequenching to 36.8%, which impairs the mitochondrial electrochemical gradient and permeability transition	Homo sapiens
physiological function	silencing of CPT2 by siRNA leads to a decrease in DNA synthesis, decreases replicating DNA by 19.9% in MDA-MB-231 cells, and results in weaker colony-forming capacities. CPT1B-depleted PANC-1 and MDA-MB-231 cells arrest the cell cycle in G1 phase. Knockdown of CPT2 downregulates the mRNA levels of ERRbeta/gamma, GABPalpha, CREB and upregulates CISD1	Homo sapiens

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Release 2023.1 (January 2023)