Cloned (Comment) | Organism |
---|---|
expression in Saccharomyces cerevisiae | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
trans-2-hexadecenoyl-CoA | competitive | Homo sapiens |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.0071 | - |
palmitoyl-CoA | pH 7.4, 37°C | Homo sapiens | |
0.0081 | - |
trans-2-hexadecenoyl-CoA | pH 7.4, 37°C | Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | P23786 | isoform CPT2 | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
4,8-dimethylnonanoyl-CoA + L-carnitine | - |
Homo sapiens | CoA + 4,8-dimethylnonanoyl-L-carnitine | - |
? | |
decanoyl-CoA + L-carnitine | - |
Homo sapiens | CoA + L-decanoylcarnitine | - |
? | |
dodecanoyl-CoA + L-carnitine | - |
Homo sapiens | CoA + L-dodecanoylcarnitine | - |
? | |
lauroyl-CoA + L-carnitine | - |
Homo sapiens | CoA + L-lauroylcarnitine | - |
? | |
additional information | isoform CPT2 is active with medium and long-chain acyl-CoA esters, whereas virtually no activity is found with short- and very long-chain acyl-CoAs or with branched-chain amino acid oxidation intermediates. Trans-2-enoyl-CoA intermediates are poor substrates, too. Isoform CPT2 is able to reverse its physiological mechanism for medium and long-chain acyl-CoAs contributing to the abnormal acylcarnitines profiles characteristic of most mitochondrial fatty acid beta-oxidation disorders | Homo sapiens | ? | - |
? | |
additional information | no substrates are: isovaleryl-CoA, isobutyryl-CoA, acetoacetyl-CoA, DL-3-hydroxybutyryl-CoA, 3-hydroxyisobutyryl-CoA, 2-methylacetoacetyl-CoA, methylcrotonyl-CoA, glutaryl-CoA, 3-hydroxy-3-methylglutaryl-CoA, 2-methylbutyryl-CoA, 2-methyl-3-hydroxybutyryl-CoA | Homo sapiens | ? | - |
? | |
myristoyl-CoA + L-carnitine | - |
Homo sapiens | CoA + L-myristoylcarnitine | - |
? | |
octanoyl-CoA + L-carnitine | - |
Homo sapiens | CoA + L-octanoylcarnitine | - |
? | |
palmitoyl-CoA + L-carnitine | - |
Homo sapiens | CoA + L-palmitoylcarnitine | - |
? | |
trans-2-hexadecenoyl-CoA + L-carnitine | - |
Homo sapiens | CoA + trans-2-hexadecenoyl-L-carnitine | - |
? |
Synonyms | Comment | Organism |
---|---|---|
CPT2 | - |
Homo sapiens |
Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
---|---|---|---|---|---|
0.0188 | - |
trans-2-hexadecenoyl-CoA | pH 7.4, 37°C | Homo sapiens |